The neuropsychological outcome of pediatric patients with refractory epilepsy treated with VNS - A 24-month follow-up in Taiwan

Jeng Dau Tsai, Ying Chao Chang, Lung Chang Lin, Kun Long Hung*, behalf of the VNS TCNS on behalf of the VNS TCNS

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

19 Scopus citations

Abstract

Objectives: Multiple studies have reported the benefits of vagus nerve stimulation (VNS) on neuropsychological outcomes. The aim of this study was to investigate how VNS affects cognition and psychosocial adjustment in children with refractory epilepsy (RE), and to determine the efficacy of VNS in a Taiwanese population. Methods: We conducted a one-group pretest-posttest study on pediatric patients with RE. The study comprised 19 males and 18 females, all aged <. 18 years. We recorded seizure frequency at 3, 12, and 24 months after VNS device implantation. Intelligence quotients (IQ) were assessed using the Wechsler Intelligence Scale for Children - IV. The Parental Stress Index (PSI) scores were evaluated by a pediatric psychologist. Results: Vagus nerve stimulation device implantation significantly reduced seizure frequency at 3, 12 and 24 months, especially in young children (<. 12 years). No significant improvement in IQ test performance was observed, though there were significant improvements in the PSI, especially in young children. Conclusions: Vagus nerve stimulation device implantation does not significantly improve cognition function, but it does significantly reduce seizure frequency and stress in parent-child relationships, especially in young children (<. 12 years). These findings suggest that VNS should be considered as an alternative therapy for patients proven to have seizures that are medically refractory, especially those younger than 12 years of age.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalEpilepsy and Behavior
Volume56
DOIs
StatePublished - 01 03 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc..

Keywords

  • Parental Stress Index
  • Pediatric patients
  • Refractory epilepsy
  • Seizures reduction
  • Vagus nerve stimulation

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