The novel desmethyldestruxin B2, from metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

Hua Chien Chen; Sheau Farn Yeh; Geok Toh Ong; Shih Hsiung Wu; Chang Ming Sun; Chen Kung Chou

doi:10.1021/np50118a007

The novel desmethyldestruxin B₂, from metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

Hua Chien Chen
, Sheau Farn Yeh^*
, Geok Toh Ong
, Shih Hsiung Wu
, Chang Ming Sun
, Chen Kung Chou

^*Corresponding author for this work

National Yang Ming Chiao Tung University
National Taiwan University
National Research Institute of Chinese Medicine
Veterans General Hospital-Taipei

Research output: Contribution to journal › Journal Article › peer-review

25 Scopus citations

Abstract

We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B₂ [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.

Original language	English
Pages (from-to)	527-531
Number of pages	5
Journal	Journal of Natural Products
Volume	58
Issue number	4
DOIs	https://doi.org/10.1021/np50118a007
State	Published - 04 1995
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1021/np50118a007

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title = "The novel desmethyldestruxin B2, from metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells",

abstract = "We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.",

author = "Chen, \{Hua Chien\} and Yeh, \{Sheau Farn\} and Ong, \{Geok Toh\} and Wu, \{Shih Hsiung\} and Sun, \{Chang Ming\} and Chou, \{Chen Kung\}",

year = "1995",

month = apr,

doi = "10.1021/np50118a007",

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pages = "527--531",

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T1 - The novel desmethyldestruxin B2, from metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

AU - Chen, Hua Chien

AU - Yeh, Sheau Farn

AU - Ong, Geok Toh

AU - Wu, Shih Hsiung

AU - Sun, Chang Ming

AU - Chou, Chen Kung

PY - 1995/4

Y1 - 1995/4

N2 - We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.

AB - We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.

UR - https://www.scopus.com/pages/publications/0029281683

U2 - 10.1021/np50118a007

DO - 10.1021/np50118a007

M3 - 文章

C2 - 7623030

AN - SCOPUS:0029281683

SN - 0163-3864

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

The novel desmethyldestruxin B₂, from metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

Abstract

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