The novel roles of four and a half LIM proteins 1 and 2 in the cardiovascular system

Pao Hsien Chu*, Ju Chen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Four and a half LIM domains protein 1 (FHL1) and FHL2, as the name suggests, contain four and a half LIM domain binding proteins. Proteins in this family capable of interacting with many types of proteins, including structural proteins, kinases, and several classes of transcription factors, have been identified. These interactions have been found to have important roles in a variety of fundamental processes including transcriptional regulation, cardiovascular development, hypertrophy, atherosclerosis, and angiogenesis. This article reviews recent advances in the characterization of FHL1 and FHL2, their biological roles, LIM domain binding proteins, and functions in the cardiovascular system.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalChang Gung Medical Journal
Volume34
Issue number2
StatePublished - 03 2011

Keywords

  • Cardiovascular system
  • FHL1
  • FHL2
  • LIM domain binding protein

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