TY - JOUR
T1 - The novel roles of four and a half LIM proteins 1 and 2 in the cardiovascular system
AU - Chu, Pao Hsien
AU - Chen, Ju
PY - 2011/3
Y1 - 2011/3
N2 - Four and a half LIM domains protein 1 (FHL1) and FHL2, as the name suggests, contain four and a half LIM domain binding proteins. Proteins in this family capable of interacting with many types of proteins, including structural proteins, kinases, and several classes of transcription factors, have been identified. These interactions have been found to have important roles in a variety of fundamental processes including transcriptional regulation, cardiovascular development, hypertrophy, atherosclerosis, and angiogenesis. This article reviews recent advances in the characterization of FHL1 and FHL2, their biological roles, LIM domain binding proteins, and functions in the cardiovascular system.
AB - Four and a half LIM domains protein 1 (FHL1) and FHL2, as the name suggests, contain four and a half LIM domain binding proteins. Proteins in this family capable of interacting with many types of proteins, including structural proteins, kinases, and several classes of transcription factors, have been identified. These interactions have been found to have important roles in a variety of fundamental processes including transcriptional regulation, cardiovascular development, hypertrophy, atherosclerosis, and angiogenesis. This article reviews recent advances in the characterization of FHL1 and FHL2, their biological roles, LIM domain binding proteins, and functions in the cardiovascular system.
KW - Cardiovascular system
KW - FHL1
KW - FHL2
KW - LIM domain binding protein
UR - http://www.scopus.com/inward/record.url?scp=79955941710&partnerID=8YFLogxK
M3 - 文献综述
C2 - 21539754
AN - SCOPUS:79955941710
SN - 0255-8270
VL - 34
SP - 127
EP - 134
JO - Chang Gung Medical Journal
JF - Chang Gung Medical Journal
IS - 2
ER -