The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma

Cheng Tung Lu; Cheng Ming Hsu; Pai Mei Lin; Chi Chih Lai; Hsin Ching Lin; Chao-Hui Yang; Hui Hua Hsiao; Yi Chang Liu; Hugo You Hsien Lin; Sheng Fung Lin; Ming Yu Yang

The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma

Cheng Tung Lu
, Cheng Ming Hsu
, Pai Mei Lin
, Chi Chih Lai
, Hsin Ching Lin
, Chao-Hui Yang
, Hui Hua Hsiao
, Yi Chang Liu
, Hugo You Hsien Lin
, Sheng Fung Lin^*
, Ming Yu Yang

^*Corresponding author for this work

Chang Gung University
I-Shou University
Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

31 Scopus citations

Abstract

Background: We have previously demonstrated altered SIRT gene family in head and neck squamous cell carcinoma (HNSCC). In the present study we aimed to investigate whether the SIRT gene family was also altered in peripheral blood (PB) of patients with HNSCC and the possibility to be used as circulating biomarkers. Patients and Methods: The expression profiles of the 7 SIRT genes of PB leukocytes from 34 patients with HNSCC before and after surgery and 31 healthy individuals were investigated. Results: In the cancer group, the expression level of SIRT1 was downregulated (p<0.05); in contrast, SIRT6 and SIRT7 were significantly up-regulated (p<0.001). Patients with advancedstage HNSCC had lower expression of SIRT1 and SIRT3. Recovery of SIRT6 and SIRT7 was observed in postoperative patients (p<0.005). Conclusion: SIRT genes were altered in PB leukocytes of HNSCC patients and SIRT6 and SIRT7 are potential circulating prognostic markers for HNSCC.

Original language	English
Pages (from-to)	7137-7143
Number of pages	7
Journal	Anticancer Research
Volume	34
Issue number	12
State	Published - 01 12 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HNSCC
Peripheral blood leukocytes
SIRT6
SIRT7
Sirtuin genes

Cite this

@article{cc6f3b7b156d46789d6ccbf2726e5243,

title = "The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma",

abstract = "Background: We have previously demonstrated altered SIRT gene family in head and neck squamous cell carcinoma (HNSCC). In the present study we aimed to investigate whether the SIRT gene family was also altered in peripheral blood (PB) of patients with HNSCC and the possibility to be used as circulating biomarkers. Patients and Methods: The expression profiles of the 7 SIRT genes of PB leukocytes from 34 patients with HNSCC before and after surgery and 31 healthy individuals were investigated. Results: In the cancer group, the expression level of SIRT1 was downregulated (p<0.05); in contrast, SIRT6 and SIRT7 were significantly up-regulated (p<0.001). Patients with advancedstage HNSCC had lower expression of SIRT1 and SIRT3. Recovery of SIRT6 and SIRT7 was observed in postoperative patients (p<0.005). Conclusion: SIRT genes were altered in PB leukocytes of HNSCC patients and SIRT6 and SIRT7 are potential circulating prognostic markers for HNSCC.",

keywords = "HNSCC, Peripheral blood leukocytes, SIRT6, SIRT7, Sirtuin genes",

author = "Lu, \{Cheng Tung\} and Hsu, \{Cheng Ming\} and Lin, \{Pai Mei\} and Lai, \{Chi Chih\} and Lin, \{Hsin Ching\} and Chao-Hui Yang and Hsiao, \{Hui Hua\} and Liu, \{Yi Chang\} and Lin, \{Hugo You Hsien\} and Lin, \{Sheng Fung\} and Yang, \{Ming Yu\}",

year = "2014",

month = dec,

day = "1",

language = "英语",

volume = "34",

pages = "7137--7143",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "12",

}

TY - JOUR

T1 - The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma

AU - Lu, Cheng Tung

AU - Hsu, Cheng Ming

AU - Lin, Pai Mei

AU - Lai, Chi Chih

AU - Lin, Hsin Ching

AU - Yang, Chao-Hui

AU - Hsiao, Hui Hua

AU - Liu, Yi Chang

AU - Lin, Hugo You Hsien

AU - Lin, Sheng Fung

AU - Yang, Ming Yu

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background: We have previously demonstrated altered SIRT gene family in head and neck squamous cell carcinoma (HNSCC). In the present study we aimed to investigate whether the SIRT gene family was also altered in peripheral blood (PB) of patients with HNSCC and the possibility to be used as circulating biomarkers. Patients and Methods: The expression profiles of the 7 SIRT genes of PB leukocytes from 34 patients with HNSCC before and after surgery and 31 healthy individuals were investigated. Results: In the cancer group, the expression level of SIRT1 was downregulated (p<0.05); in contrast, SIRT6 and SIRT7 were significantly up-regulated (p<0.001). Patients with advancedstage HNSCC had lower expression of SIRT1 and SIRT3. Recovery of SIRT6 and SIRT7 was observed in postoperative patients (p<0.005). Conclusion: SIRT genes were altered in PB leukocytes of HNSCC patients and SIRT6 and SIRT7 are potential circulating prognostic markers for HNSCC.

AB - Background: We have previously demonstrated altered SIRT gene family in head and neck squamous cell carcinoma (HNSCC). In the present study we aimed to investigate whether the SIRT gene family was also altered in peripheral blood (PB) of patients with HNSCC and the possibility to be used as circulating biomarkers. Patients and Methods: The expression profiles of the 7 SIRT genes of PB leukocytes from 34 patients with HNSCC before and after surgery and 31 healthy individuals were investigated. Results: In the cancer group, the expression level of SIRT1 was downregulated (p<0.05); in contrast, SIRT6 and SIRT7 were significantly up-regulated (p<0.001). Patients with advancedstage HNSCC had lower expression of SIRT1 and SIRT3. Recovery of SIRT6 and SIRT7 was observed in postoperative patients (p<0.005). Conclusion: SIRT genes were altered in PB leukocytes of HNSCC patients and SIRT6 and SIRT7 are potential circulating prognostic markers for HNSCC.

KW - HNSCC

KW - Peripheral blood leukocytes

KW - SIRT6

KW - SIRT7

KW - Sirtuin genes

UR - https://www.scopus.com/pages/publications/84918559371

M3 - 文章

C2 - 25503141

AN - SCOPUS:84918559371

SN - 0250-7005

VL - 34

SP - 7137

EP - 7143

JO - Anticancer Research

JF - Anticancer Research

IS - 12

ER -

The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma

Abstract

UN SDGs

Keywords

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