The prognostic roles of pretreatment circulating tumor cells, circulating cancer stem-like cells, and programmed cell death-1 expression on peripheral lymphocytes in patients with initially unresectable, recurrent or metastatic head and neck cancer: An exploratory study of three biomarkers in one-time blood drawing

Pei Hung Chang; Min Hsien Wu; Sen Yu Liu; Hung Ming Wang; Wen Kuan Huang; Chun Ta Liao; Tzu Chen Yen; Shu Hang Ng; Jen Shi Chen; Yung Chang Lin; Hung Chih Lin; Jason Chia Hsun Hsieh

doi:10.3390/cancers11040540

The prognostic roles of pretreatment circulating tumor cells, circulating cancer stem-like cells, and programmed cell death-1 expression on peripheral lymphocytes in patients with initially unresectable, recurrent or metastatic head and neck cancer: An exploratory study of three biomarkers in one-time blood drawing

Pei Hung Chang^*, Min Hsien Wu, Sen Yu Liu, Hung Ming Wang, Wen Kuan Huang, Chun Ta Liao, Tzu Chen Yen, Shu Hang Ng, Jen Shi Chen, Yung Chang Lin, Hung Chih Lin, Jason Chia Hsun Hsieh

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

13 Scopus citations

Abstract

Circulating tumor cells (CTCs) and immune status are strongly related to cancer prognosis, although few studies have examined both factors. This prospective observational study (ClinicalTrials.gov: NCT02420600) evaluated whether CTCs, circulating cancer stem-like cells (cCSCs), and peripheral lymphocytes with/without Programmed cell death protein 1 (PD-1) expression were associated with prognosis among patients receiving palliative chemotherapy for initially unresectable, recurrent/metastatic head and neck squamous cell carcinoma (rmHNSCC). Thirty-four patients were enrolled between January 2015 and June 2016. Overall survival (OS) was associated with a higher CTC number (hazard ratio [HR]: 1.01, p = 0.0004) and cCSC ratio (HR: 29.903, p < 0.0001). Progression-free survival (PFS) was also associated with CTC number (HR: 1.013, p = 0.002) and cCSC ratio (HR: 10.92 p = 0.003). A CD8+ proportion of _ 17% was associated with improved OS (HR: 0.242, p = 0.004). A CD4: CD8 ratio of >1.2 was associated with poorer trend of PFS (HR: 2.12, p = 0.064). PD-1 expression was not associated with survival outcomes. Baseline CTCs, cCSC ratio, and CD8+ ratio may predict prognosis in rmHNSCC.

Original language	English
Article number	540
Journal	Cancers
Volume	11
Issue number	4
DOIs	https://doi.org/10.3390/cancers11040540
State	Published - 04 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cancer stem-like cells
Circulating tumor cells
Head and neck cancer
PD-1
Peripheral lymphocytes

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Chang, P. H., Wu, M. H., Liu, S. Y., Wang, H. M., Huang, W. K., Liao, C. T., Yen, T. C., Ng, S. H., Chen, J. S., Lin, Y. C., Lin, H. C., & Hsieh, J. C. H. (2019). The prognostic roles of pretreatment circulating tumor cells, circulating cancer stem-like cells, and programmed cell death-1 expression on peripheral lymphocytes in patients with initially unresectable, recurrent or metastatic head and neck cancer: An exploratory study of three biomarkers in one-time blood drawing. Cancers, 11(4), Article 540. https://doi.org/10.3390/cancers11040540

Chang, Pei Hung ; Wu, Min Hsien ; Liu, Sen Yu et al. / The prognostic roles of pretreatment circulating tumor cells, circulating cancer stem-like cells, and programmed cell death-1 expression on peripheral lymphocytes in patients with initially unresectable, recurrent or metastatic head and neck cancer : An exploratory study of three biomarkers in one-time blood drawing. In: Cancers. 2019 ; Vol. 11, No. 4.

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title = "The prognostic roles of pretreatment circulating tumor cells, circulating cancer stem-like cells, and programmed cell death-1 expression on peripheral lymphocytes in patients with initially unresectable, recurrent or metastatic head and neck cancer: An exploratory study of three biomarkers in one-time blood drawing",

abstract = "Circulating tumor cells (CTCs) and immune status are strongly related to cancer prognosis, although few studies have examined both factors. This prospective observational study (ClinicalTrials.gov: NCT02420600) evaluated whether CTCs, circulating cancer stem-like cells (cCSCs), and peripheral lymphocytes with/without Programmed cell death protein 1 (PD-1) expression were associated with prognosis among patients receiving palliative chemotherapy for initially unresectable, recurrent/metastatic head and neck squamous cell carcinoma (rmHNSCC). Thirty-four patients were enrolled between January 2015 and June 2016. Overall survival (OS) was associated with a higher CTC number (hazard ratio [HR]: 1.01, p = 0.0004) and cCSC ratio (HR: 29.903, p < 0.0001). Progression-free survival (PFS) was also associated with CTC number (HR: 1.013, p = 0.002) and cCSC ratio (HR: 10.92 p = 0.003). A CD8+ proportion of _ 17% was associated with improved OS (HR: 0.242, p = 0.004). A CD4: CD8 ratio of >1.2 was associated with poorer trend of PFS (HR: 2.12, p = 0.064). PD-1 expression was not associated with survival outcomes. Baseline CTCs, cCSC ratio, and CD8+ ratio may predict prognosis in rmHNSCC.",

keywords = "Cancer stem-like cells, Circulating tumor cells, Head and neck cancer, PD-1, Peripheral lymphocytes",

author = "Chang, {Pei Hung} and Wu, {Min Hsien} and Liu, {Sen Yu} and Wang, {Hung Ming} and Huang, {Wen Kuan} and Liao, {Chun Ta} and Yen, {Tzu Chen} and Ng, {Shu Hang} and Chen, {Jen Shi} and Lin, {Yung Chang} and Lin, {Hung Chih} and Hsieh, {Jason Chia Hsun}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = apr,

doi = "10.3390/cancers11040540",

language = "英语",

volume = "11",

journal = "Cancers",

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Chang, PH , Wu, MH, Liu, SY, Wang, HM , Huang, WK, Liao, CT, Yen, TC, Ng, SH, Chen, JS, Lin, YC, Lin, HC & Hsieh, JCH 2019, 'The prognostic roles of pretreatment circulating tumor cells, circulating cancer stem-like cells, and programmed cell death-1 expression on peripheral lymphocytes in patients with initially unresectable, recurrent or metastatic head and neck cancer: An exploratory study of three biomarkers in one-time blood drawing', Cancers, vol. 11, no. 4, 540. https://doi.org/10.3390/cancers11040540

The prognostic roles of pretreatment circulating tumor cells, circulating cancer stem-like cells, and programmed cell death-1 expression on peripheral lymphocytes in patients with initially unresectable, recurrent or metastatic head and neck cancer: An exploratory study of three biomarkers in one-time blood drawing. / Chang, Pei Hung ; Wu, Min Hsien; Liu, Sen Yu et al.
In: Cancers, Vol. 11, No. 4, 540, 04.2019.

Research output: Contribution to journal › Journal Article › peer-review

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T2 - An exploratory study of three biomarkers in one-time blood drawing

AU - Chang, Pei Hung

AU - Wu, Min Hsien

AU - Liu, Sen Yu

AU - Wang, Hung Ming

AU - Huang, Wen Kuan

AU - Liao, Chun Ta

AU - Yen, Tzu Chen

AU - Ng, Shu Hang

AU - Chen, Jen Shi

AU - Lin, Yung Chang

AU - Lin, Hung Chih

AU - Hsieh, Jason Chia Hsun

PY - 2019/4

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N2 - Circulating tumor cells (CTCs) and immune status are strongly related to cancer prognosis, although few studies have examined both factors. This prospective observational study (ClinicalTrials.gov: NCT02420600) evaluated whether CTCs, circulating cancer stem-like cells (cCSCs), and peripheral lymphocytes with/without Programmed cell death protein 1 (PD-1) expression were associated with prognosis among patients receiving palliative chemotherapy for initially unresectable, recurrent/metastatic head and neck squamous cell carcinoma (rmHNSCC). Thirty-four patients were enrolled between January 2015 and June 2016. Overall survival (OS) was associated with a higher CTC number (hazard ratio [HR]: 1.01, p = 0.0004) and cCSC ratio (HR: 29.903, p < 0.0001). Progression-free survival (PFS) was also associated with CTC number (HR: 1.013, p = 0.002) and cCSC ratio (HR: 10.92 p = 0.003). A CD8+ proportion of _ 17% was associated with improved OS (HR: 0.242, p = 0.004). A CD4: CD8 ratio of >1.2 was associated with poorer trend of PFS (HR: 2.12, p = 0.064). PD-1 expression was not associated with survival outcomes. Baseline CTCs, cCSC ratio, and CD8+ ratio may predict prognosis in rmHNSCC.

AB - Circulating tumor cells (CTCs) and immune status are strongly related to cancer prognosis, although few studies have examined both factors. This prospective observational study (ClinicalTrials.gov: NCT02420600) evaluated whether CTCs, circulating cancer stem-like cells (cCSCs), and peripheral lymphocytes with/without Programmed cell death protein 1 (PD-1) expression were associated with prognosis among patients receiving palliative chemotherapy for initially unresectable, recurrent/metastatic head and neck squamous cell carcinoma (rmHNSCC). Thirty-four patients were enrolled between January 2015 and June 2016. Overall survival (OS) was associated with a higher CTC number (hazard ratio [HR]: 1.01, p = 0.0004) and cCSC ratio (HR: 29.903, p < 0.0001). Progression-free survival (PFS) was also associated with CTC number (HR: 1.013, p = 0.002) and cCSC ratio (HR: 10.92 p = 0.003). A CD8+ proportion of _ 17% was associated with improved OS (HR: 0.242, p = 0.004). A CD4: CD8 ratio of >1.2 was associated with poorer trend of PFS (HR: 2.12, p = 0.064). PD-1 expression was not associated with survival outcomes. Baseline CTCs, cCSC ratio, and CD8+ ratio may predict prognosis in rmHNSCC.

KW - Cancer stem-like cells

KW - Circulating tumor cells

KW - Head and neck cancer

KW - PD-1

KW - Peripheral lymphocytes

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Chang PH , Wu MH, Liu SY, Wang HM , Huang WK, Liao CT et al. The prognostic roles of pretreatment circulating tumor cells, circulating cancer stem-like cells, and programmed cell death-1 expression on peripheral lymphocytes in patients with initially unresectable, recurrent or metastatic head and neck cancer: An exploratory study of three biomarkers in one-time blood drawing. Cancers. 2019 Apr;11(4):540. doi: 10.3390/cancers11040540