The prognostic value of serial leukocyte adhesion molecules in post-aneurysmal subarachnoid hemorrhage

Tzu Ming Yang; Yu Jun Lin; Nai Wen Tsai; Wei Che Lin; Jih Tsun Ho; Wen Neng Chang; Ben Chung Cheng; Chia Te Kung; Tsung Han Lee; Chih Cheng Huang; Hung Chen Wang; Cheng Hsien Lu

doi:10.1016/j.cca.2011.10.007

The prognostic value of serial leukocyte adhesion molecules in post-aneurysmal subarachnoid hemorrhage

Tzu Ming Yang, Yu Jun Lin, Nai Wen Tsai, Wei Che Lin, Jih Tsun Ho, Wen Neng Chang, Ben Chung Cheng, Chia Te Kung, Tsung Han Lee, Chih Cheng Huang, Hung Chen Wang, Cheng Hsien Lu^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

Background: Leukocyte recruitment and inflammatory response play an important role in the pathophysiology after aneurysmal subarachnoid hemorrhage (SAH). We determined whether leukocyte adhesion molecules after aneurysmal SAH can predict the presence of delayed cerebral infarction (DCI). Methods: Serial changes in P-selectin glycoprotein ligand-1 (PSGL-1), macrophage antigen-1 (Mac-1), and lymphocyte function-associated antigen-1 (LFA-1) expression by leukocyte subsets were prospectively examined using flow cytometry at various time points in 20 acute aneurysmal SAH patients and 21 healthy volunteers who were free of medications were enrolled as a control group. Results: Neutrophil (cut-off value of > 44.90) and monocyte (cut-off value of > 32.95) PSGL-1 expressions on admission were significantly higher in patients with DCI than in non-DCI patients, but the difference between neutrophil PGSL-1 and monocyte PGSL-1 levels between the two groups was no longer significant from Day 4 to Day 14 after aneurysmal SAH. After stepwise logistic regression analysis, only neutrophil PSGL-1 expression upon admission was independently associated with DCI. The mean hospitalization days were 44.4 ± 26.2 for those patients with DCI and 40.5 ± 26.4 for non-DCI patients. After a minimum 6-month follow-up period, the median BI score was 20 for DCI patients and 80 for non-DCI patients. Conclusions: Higher expressions of neutrophil PSGL-1 on admission may imply a danger of DCI in patients with aneurysmal SAH.

Original language	English
Pages (from-to)	411-416
Number of pages	6
Journal	Clinica Chimica Acta
Volume	413
Issue number	3-4
DOIs	https://doi.org/10.1016/j.cca.2011.10.007
State	Published - 18 02 2012

Keywords

Aneurysmal subarachnoid hemorrhage
Leukocytes
Lymphocyte function-associated antigen-1
Macrophage antigen-1
P-selectin glycoprotein ligand-1

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10.1016/j.cca.2011.10.007

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@article{61640d8af4bc4c30a3a0cab9e612cae2,

title = "The prognostic value of serial leukocyte adhesion molecules in post-aneurysmal subarachnoid hemorrhage",

abstract = "Background: Leukocyte recruitment and inflammatory response play an important role in the pathophysiology after aneurysmal subarachnoid hemorrhage (SAH). We determined whether leukocyte adhesion molecules after aneurysmal SAH can predict the presence of delayed cerebral infarction (DCI). Methods: Serial changes in P-selectin glycoprotein ligand-1 (PSGL-1), macrophage antigen-1 (Mac-1), and lymphocyte function-associated antigen-1 (LFA-1) expression by leukocyte subsets were prospectively examined using flow cytometry at various time points in 20 acute aneurysmal SAH patients and 21 healthy volunteers who were free of medications were enrolled as a control group. Results: Neutrophil (cut-off value of > 44.90) and monocyte (cut-off value of > 32.95) PSGL-1 expressions on admission were significantly higher in patients with DCI than in non-DCI patients, but the difference between neutrophil PGSL-1 and monocyte PGSL-1 levels between the two groups was no longer significant from Day 4 to Day 14 after aneurysmal SAH. After stepwise logistic regression analysis, only neutrophil PSGL-1 expression upon admission was independently associated with DCI. The mean hospitalization days were 44.4 ± 26.2 for those patients with DCI and 40.5 ± 26.4 for non-DCI patients. After a minimum 6-month follow-up period, the median BI score was 20 for DCI patients and 80 for non-DCI patients. Conclusions: Higher expressions of neutrophil PSGL-1 on admission may imply a danger of DCI in patients with aneurysmal SAH.",

keywords = "Aneurysmal subarachnoid hemorrhage, Leukocytes, Lymphocyte function-associated antigen-1, Macrophage antigen-1, P-selectin glycoprotein ligand-1",

author = "Yang, {Tzu Ming} and Lin, {Yu Jun} and Tsai, {Nai Wen} and Lin, {Wei Che} and Ho, {Jih Tsun} and Chang, {Wen Neng} and Cheng, {Ben Chung} and Kung, {Chia Te} and Lee, {Tsung Han} and Huang, {Chih Cheng} and Wang, {Hung Chen} and Lu, {Cheng Hsien}",

year = "2012",

month = feb,

day = "18",

doi = "10.1016/j.cca.2011.10.007",

language = "英语",

volume = "413",

pages = "411--416",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier B.V.",

number = "3-4",

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TY - JOUR

T1 - The prognostic value of serial leukocyte adhesion molecules in post-aneurysmal subarachnoid hemorrhage

AU - Yang, Tzu Ming

AU - Lin, Yu Jun

AU - Tsai, Nai Wen

AU - Lin, Wei Che

AU - Ho, Jih Tsun

AU - Chang, Wen Neng

AU - Cheng, Ben Chung

AU - Kung, Chia Te

AU - Lee, Tsung Han

AU - Huang, Chih Cheng

AU - Wang, Hung Chen

AU - Lu, Cheng Hsien

PY - 2012/2/18

Y1 - 2012/2/18

N2 - Background: Leukocyte recruitment and inflammatory response play an important role in the pathophysiology after aneurysmal subarachnoid hemorrhage (SAH). We determined whether leukocyte adhesion molecules after aneurysmal SAH can predict the presence of delayed cerebral infarction (DCI). Methods: Serial changes in P-selectin glycoprotein ligand-1 (PSGL-1), macrophage antigen-1 (Mac-1), and lymphocyte function-associated antigen-1 (LFA-1) expression by leukocyte subsets were prospectively examined using flow cytometry at various time points in 20 acute aneurysmal SAH patients and 21 healthy volunteers who were free of medications were enrolled as a control group. Results: Neutrophil (cut-off value of > 44.90) and monocyte (cut-off value of > 32.95) PSGL-1 expressions on admission were significantly higher in patients with DCI than in non-DCI patients, but the difference between neutrophil PGSL-1 and monocyte PGSL-1 levels between the two groups was no longer significant from Day 4 to Day 14 after aneurysmal SAH. After stepwise logistic regression analysis, only neutrophil PSGL-1 expression upon admission was independently associated with DCI. The mean hospitalization days were 44.4 ± 26.2 for those patients with DCI and 40.5 ± 26.4 for non-DCI patients. After a minimum 6-month follow-up period, the median BI score was 20 for DCI patients and 80 for non-DCI patients. Conclusions: Higher expressions of neutrophil PSGL-1 on admission may imply a danger of DCI in patients with aneurysmal SAH.

AB - Background: Leukocyte recruitment and inflammatory response play an important role in the pathophysiology after aneurysmal subarachnoid hemorrhage (SAH). We determined whether leukocyte adhesion molecules after aneurysmal SAH can predict the presence of delayed cerebral infarction (DCI). Methods: Serial changes in P-selectin glycoprotein ligand-1 (PSGL-1), macrophage antigen-1 (Mac-1), and lymphocyte function-associated antigen-1 (LFA-1) expression by leukocyte subsets were prospectively examined using flow cytometry at various time points in 20 acute aneurysmal SAH patients and 21 healthy volunteers who were free of medications were enrolled as a control group. Results: Neutrophil (cut-off value of > 44.90) and monocyte (cut-off value of > 32.95) PSGL-1 expressions on admission were significantly higher in patients with DCI than in non-DCI patients, but the difference between neutrophil PGSL-1 and monocyte PGSL-1 levels between the two groups was no longer significant from Day 4 to Day 14 after aneurysmal SAH. After stepwise logistic regression analysis, only neutrophil PSGL-1 expression upon admission was independently associated with DCI. The mean hospitalization days were 44.4 ± 26.2 for those patients with DCI and 40.5 ± 26.4 for non-DCI patients. After a minimum 6-month follow-up period, the median BI score was 20 for DCI patients and 80 for non-DCI patients. Conclusions: Higher expressions of neutrophil PSGL-1 on admission may imply a danger of DCI in patients with aneurysmal SAH.

KW - Aneurysmal subarachnoid hemorrhage

KW - Leukocytes

KW - Lymphocyte function-associated antigen-1

KW - Macrophage antigen-1

KW - P-selectin glycoprotein ligand-1

UR - http://www.scopus.com/inward/record.url?scp=84355161444&partnerID=8YFLogxK

U2 - 10.1016/j.cca.2011.10.007

DO - 10.1016/j.cca.2011.10.007

M3 - 文章

C2 - 22074931

AN - SCOPUS:84355161444

SN - 0009-8981

VL - 413

SP - 411

EP - 416

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 3-4

ER -

The prognostic value of serial leukocyte adhesion molecules in post-aneurysmal subarachnoid hemorrhage

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Keywords

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