TY - JOUR
T1 - The relationship between plasma sphingosine-1-phosphate, plasma apolipoprotein M, obesity, and the risk of incident type 2 diabetes
T2 - a prospective cohort study
AU - Fan, Kang Chih
AU - Yen, I. Weng
AU - Lin, Chia Hung
AU - Yang, Chung Yi
AU - Kuo, Chun Heng
AU - Chen, Szu Chi
AU - Lyu, Ya Pin
AU - Juan, Hsien Chia
AU - Lin, Mao Shin
AU - Wang, Shu Huei
AU - Li, Hung Yuan
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature Limited 2025.
PY - 2025/11
Y1 - 2025/11
N2 - Objectives: Type 2 diabetes (T2D) is a growing global health challenge, necessitating novel biomarkers for early risk assessment. This study investigates the associations between plasma sphingosine-1-phosphate (S1P), apolipoprotein M (ApoM), obesity measures, and the risk of incident T2D. Methods: We utilized data from the Taiwan Lifestyle Study, a prospective cohort initiated in 2006. A total of 1207 individuals without diabetes at baseline were included. Abdominal fat distribution was assessed using computed tomography, while plasma S1P and ApoM levels were measured using ELISA. Results: During an average follow-up of 5.93 years, 152 participants developed diabetes. Plasma S1P correlated with visceral, peritoneal, and retroperitoneal fat (all p < 0.001), while ApoM correlated with total, subcutaneous, and visceral fat (all p < 0.001). In adjusted models, plasma S1P significantly predicted diabetes (HR 0.52, 95% CI 0.35–0.77, p = 0.001), whereas plasma ApoM did not (HR 1.16, 95% CI 0.94–1.43, p = 0.170). The predictive model incorporating S1P showed an AUC of 0.7698 and a concordance statistic of 0.7637, outperforming traditional risk factors. Conclusions: Plasma S1P and ApoM are both associated with obesity. However, only plasma S1P is a good predictive biomarker for incident T2D, underscoring its potential for early risk assessment and intervention.
AB - Objectives: Type 2 diabetes (T2D) is a growing global health challenge, necessitating novel biomarkers for early risk assessment. This study investigates the associations between plasma sphingosine-1-phosphate (S1P), apolipoprotein M (ApoM), obesity measures, and the risk of incident T2D. Methods: We utilized data from the Taiwan Lifestyle Study, a prospective cohort initiated in 2006. A total of 1207 individuals without diabetes at baseline were included. Abdominal fat distribution was assessed using computed tomography, while plasma S1P and ApoM levels were measured using ELISA. Results: During an average follow-up of 5.93 years, 152 participants developed diabetes. Plasma S1P correlated with visceral, peritoneal, and retroperitoneal fat (all p < 0.001), while ApoM correlated with total, subcutaneous, and visceral fat (all p < 0.001). In adjusted models, plasma S1P significantly predicted diabetes (HR 0.52, 95% CI 0.35–0.77, p = 0.001), whereas plasma ApoM did not (HR 1.16, 95% CI 0.94–1.43, p = 0.170). The predictive model incorporating S1P showed an AUC of 0.7698 and a concordance statistic of 0.7637, outperforming traditional risk factors. Conclusions: Plasma S1P and ApoM are both associated with obesity. However, only plasma S1P is a good predictive biomarker for incident T2D, underscoring its potential for early risk assessment and intervention.
UR - https://www.scopus.com/pages/publications/105014151359
U2 - 10.1038/s41366-025-01890-7
DO - 10.1038/s41366-025-01890-7
M3 - 文章
AN - SCOPUS:105014151359
SN - 0307-0565
VL - 49
SP - 2320
EP - 2326
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 11
ER -
