TY - JOUR
T1 - The risk of stroke after percutaneous vertebroplasty for osteoporosis
T2 - A population-based cohort study
AU - Wu, Ching Lan
AU - Wu, Jau Ching
AU - Huang, Wen Cheng
AU - Wu, Hung Ta H.
AU - Chiou, Hong Jen
AU - Liu, Laura
AU - Chen, Yu Chun
AU - Chen, Tzeng Ji
AU - Cheng, Henrich
AU - Chang, Cheng Yen
PY - 2012/1/31
Y1 - 2012/1/31
N2 - Purpose: To investigate the incidence and risk of stroke after percutaneous vertebroplasty in patients with osteoporosis. Methods: A group of 334 patients with osteoporosis, and who underwent percutaneous vertebroplasty during the study period, was compared to 1,655 age-, sex- and propensity score-matched patients who did not undergo vertebroplasty. All demographic covariates and co-morbidities were deliberately matched between the two groups to avoid selection bias. Every subject was followed-up for up to five years for stroke. Adjustments using a Cox regression model and Kaplan-Meier analyses were conducted. Results: A total of 1,989 osteoporotic patients were followed up for 3,760.13 person-years. Overall, the incidence rates of any stroke, hemorrhagic stroke and ischemic stroke were 22.6, 4.2 and 19.6 per 1,000 person-years, respectively. Patients who underwent vertebroplasty were not more likely to have any stroke (crude hazard ratio = 1.13, p = 0.693), hemorrhagic stroke (HR = 2.21, p = 0.170), or ischemic stroke (HR = 0.96, p = 0.90). After adjusting for demographics, co-morbidities and medications, the vertebroplasty group had no significant difference with the comparison group in terms of any, hemorrhagic and ischemic strokes (adjusted HR = 1.22, 3.17, and 0.96, p = 0.518, 0.055, and 0.91, respectively). Conclusions: Osteoporotic patients who undergo percutaneous vertebroplasty are not at higher risk of any stroke in the next five years after the procedure.
AB - Purpose: To investigate the incidence and risk of stroke after percutaneous vertebroplasty in patients with osteoporosis. Methods: A group of 334 patients with osteoporosis, and who underwent percutaneous vertebroplasty during the study period, was compared to 1,655 age-, sex- and propensity score-matched patients who did not undergo vertebroplasty. All demographic covariates and co-morbidities were deliberately matched between the two groups to avoid selection bias. Every subject was followed-up for up to five years for stroke. Adjustments using a Cox regression model and Kaplan-Meier analyses were conducted. Results: A total of 1,989 osteoporotic patients were followed up for 3,760.13 person-years. Overall, the incidence rates of any stroke, hemorrhagic stroke and ischemic stroke were 22.6, 4.2 and 19.6 per 1,000 person-years, respectively. Patients who underwent vertebroplasty were not more likely to have any stroke (crude hazard ratio = 1.13, p = 0.693), hemorrhagic stroke (HR = 2.21, p = 0.170), or ischemic stroke (HR = 0.96, p = 0.90). After adjusting for demographics, co-morbidities and medications, the vertebroplasty group had no significant difference with the comparison group in terms of any, hemorrhagic and ischemic strokes (adjusted HR = 1.22, 3.17, and 0.96, p = 0.518, 0.055, and 0.91, respectively). Conclusions: Osteoporotic patients who undergo percutaneous vertebroplasty are not at higher risk of any stroke in the next five years after the procedure.
UR - https://www.scopus.com/pages/publications/84856444498
U2 - 10.1371/journal.pone.0031405
DO - 10.1371/journal.pone.0031405
M3 - 文章
C2 - 22303486
AN - SCOPUS:84856444498
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 1
M1 - e31405
ER -
