TY - JOUR
T1 - The Role of BPIFA1 in Upper Airway Microbial Infections and Correlated Diseases
AU - Tsou, Yung An
AU - Tung, Min Che
AU - Alexander, Katherine A.
AU - Chang, Wen Dien
AU - Tsai, Ming Hsui
AU - Chen, Hsiao Ling
AU - Chen, Chuan Mu
N1 - Publisher Copyright:
© 2018 Yung-An Tsou et al.
PY - 2018
Y1 - 2018
N2 - The mucosa is part of the first line of immune defense against pathogen exposure in humans and prevents viral and bacterial infection of the soft palate, lungs, uvula, and nasal cavity that comprise the ear-nose-throat (ENT) region. Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases. This review will provide a brief introduction of the roles of BPIFA1 in the upper airway (with a focus on the nasal cavity, sinus, and middle ear), specifically its history, identification, distribution in various human tissues, function, and diagnostic value in various upper airway infectious diseases.
AB - The mucosa is part of the first line of immune defense against pathogen exposure in humans and prevents viral and bacterial infection of the soft palate, lungs, uvula, and nasal cavity that comprise the ear-nose-throat (ENT) region. Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases. This review will provide a brief introduction of the roles of BPIFA1 in the upper airway (with a focus on the nasal cavity, sinus, and middle ear), specifically its history, identification, distribution in various human tissues, function, and diagnostic value in various upper airway infectious diseases.
UR - http://www.scopus.com/inward/record.url?scp=85053713212&partnerID=8YFLogxK
U2 - 10.1155/2018/2021890
DO - 10.1155/2018/2021890
M3 - 文献综述
C2 - 30255091
AN - SCOPUS:85053713212
SN - 2314-6133
VL - 2018
JO - BioMed Research International
JF - BioMed Research International
M1 - 2021890
ER -
