The role of delta superinfection in acute exacerbations of chronic type B hepatitis

Chia‐Ming ‐M Chu; Patrizia Farci; Yun‐Fan ‐F Liaw; Angelo Balestrieri; Howard C. Thomas

doi:10.1111/j.1600-0676.1986.tb00264.x

The role of delta superinfection in acute exacerbations of chronic type B hepatitis

Chia‐Ming ‐M Chu
, Patrizia Farci
, Yun‐Fan ‐F Liaw^*
, Angelo Balestrieri
, Howard C. Thomas

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

15 Scopus citations

Abstract

ABSTRACT— Serum specimens collected from patients with chronic type B hepatitis during their acute exacerbations were studied with radioimmunoassay for serological markers of delta (δ) agent infection. Serum δ antigen was negative in all 56 hepatitis B e antigen (HBeAg)‐positive and 25 anti‐HBe‐positive acute exacerbations. Two (3.6%) HBeAg‐positive and five (20%) anti‐HBe‐positive acute exacerbations were found to be positive for both IgG anti‐δ and IgM anti‐δ. The incidence in anti‐HBe‐positive patients was significantly higher than in HBeAg‐positive patients. These results indicated that some of the acute exacerbations, particularly in anti‐HBe‐positive phase, could be attributed to δ‐superinfection. However, acute exacerbations preceding HBeAg/anti‐HBe seroconversion were not associated with δ‐superinfection.

Original language	English
Pages (from-to)	26-29
Number of pages	4
Journal	Liver
Volume	6
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0676.1986.tb00264.x
State	Published - 02 1986
Externally published	Yes

Keywords

acute exacerbation
chronic type B hepatitis
delta agent
hepatitis B e antigen/antibody (HBeAg/anti‐HBe)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0676.1986.tb00264.x

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title = "The role of delta superinfection in acute exacerbations of chronic type B hepatitis",

abstract = "ABSTRACT— Serum specimens collected from patients with chronic type B hepatitis during their acute exacerbations were studied with radioimmunoassay for serological markers of delta (δ) agent infection. Serum δ antigen was negative in all 56 hepatitis B e antigen (HBeAg)‐positive and 25 anti‐HBe‐positive acute exacerbations. Two (3.6\%) HBeAg‐positive and five (20\%) anti‐HBe‐positive acute exacerbations were found to be positive for both IgG anti‐δ and IgM anti‐δ. The incidence in anti‐HBe‐positive patients was significantly higher than in HBeAg‐positive patients. These results indicated that some of the acute exacerbations, particularly in anti‐HBe‐positive phase, could be attributed to δ‐superinfection. However, acute exacerbations preceding HBeAg/anti‐HBe seroconversion were not associated with δ‐superinfection.",

keywords = "acute exacerbation, chronic type B hepatitis, delta agent, hepatitis B e antigen/antibody (HBeAg/anti‐HBe)",

author = "Chu, \{Chia‐Ming ‐M\} and Patrizia Farci and Liaw, \{Yun‐Fan ‐F\} and Angelo Balestrieri and Thomas, \{Howard C.\}",

year = "1986",

month = feb,

doi = "10.1111/j.1600-0676.1986.tb00264.x",

language = "英语",

volume = "6",

pages = "26--29",

journal = "Liver",

issn = "0106-9543",

publisher = "Wiley-Blackwell Publishing Ltd",

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TY - JOUR

T1 - The role of delta superinfection in acute exacerbations of chronic type B hepatitis

AU - Chu, Chia‐Ming ‐M

AU - Farci, Patrizia

AU - Liaw, Yun‐Fan ‐F

AU - Balestrieri, Angelo

AU - Thomas, Howard C.

PY - 1986/2

Y1 - 1986/2

N2 - ABSTRACT— Serum specimens collected from patients with chronic type B hepatitis during their acute exacerbations were studied with radioimmunoassay for serological markers of delta (δ) agent infection. Serum δ antigen was negative in all 56 hepatitis B e antigen (HBeAg)‐positive and 25 anti‐HBe‐positive acute exacerbations. Two (3.6%) HBeAg‐positive and five (20%) anti‐HBe‐positive acute exacerbations were found to be positive for both IgG anti‐δ and IgM anti‐δ. The incidence in anti‐HBe‐positive patients was significantly higher than in HBeAg‐positive patients. These results indicated that some of the acute exacerbations, particularly in anti‐HBe‐positive phase, could be attributed to δ‐superinfection. However, acute exacerbations preceding HBeAg/anti‐HBe seroconversion were not associated with δ‐superinfection.

AB - ABSTRACT— Serum specimens collected from patients with chronic type B hepatitis during their acute exacerbations were studied with radioimmunoassay for serological markers of delta (δ) agent infection. Serum δ antigen was negative in all 56 hepatitis B e antigen (HBeAg)‐positive and 25 anti‐HBe‐positive acute exacerbations. Two (3.6%) HBeAg‐positive and five (20%) anti‐HBe‐positive acute exacerbations were found to be positive for both IgG anti‐δ and IgM anti‐δ. The incidence in anti‐HBe‐positive patients was significantly higher than in HBeAg‐positive patients. These results indicated that some of the acute exacerbations, particularly in anti‐HBe‐positive phase, could be attributed to δ‐superinfection. However, acute exacerbations preceding HBeAg/anti‐HBe seroconversion were not associated with δ‐superinfection.

KW - acute exacerbation

KW - chronic type B hepatitis

KW - delta agent

KW - hepatitis B e antigen/antibody (HBeAg/anti‐HBe)

UR - https://www.scopus.com/pages/publications/0022580091

U2 - 10.1111/j.1600-0676.1986.tb00264.x

DO - 10.1111/j.1600-0676.1986.tb00264.x

M3 - 文章

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AN - SCOPUS:0022580091

SN - 0106-9543

VL - 6

SP - 26

EP - 29

JO - Liver

JF - Liver

IS - 1

ER -

The role of delta superinfection in acute exacerbations of chronic type B hepatitis

Abstract

Keywords

UN SDGs

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