The role of GPR56/ADGRG1 in health and disease

Abhishek Kumar Singh; Hsi Hsien Lin

doi:10.1016/j.bj.2021.04.012

The role of GPR56/ADGRG1 in health and disease

Abhishek Kumar Singh, Hsi Hsien Lin^*

^*Corresponding author for this work

Department of Microbiology and Immunology

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.

Original language	English
Pages (from-to)	534-547
Number of pages	14
Journal	Biomedical Journal
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/j.bj.2021.04.012
State	Published - 10 2021

Bibliographical note

Publisher Copyright:
© 2021 Chang Gung University

Keywords

Adhesion GPCR
G protein
Ligand
Signaling

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10.1016/j.bj.2021.04.012

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abstract = "GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.",

keywords = "Adhesion GPCR, G protein, Ligand, Signaling",

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AB - GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.

KW - Adhesion GPCR

KW - G protein

KW - Ligand

KW - Signaling

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JO - Biomedical Journal

JF - Biomedical Journal

IS - 5

ER -

The role of GPR56/ADGRG1 in health and disease

Abstract

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Keywords

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