The role of hepatitis B and C viruses in hepatocellular carcinoma in a hepatitis B endemic area. A case‐control study

Wan‐Long ‐L Chuang; Wen‐Yu ‐Y Chang; Sheng‐Nan ‐N Lu; Wang‐Pin ‐P Su; Zu‐Yau ‐Y Lin; Shinn‐Cherng ‐C Chen; Ming‐Yuh ‐Y Hsieh; Liang‐Yen ‐Y Wang; San‐Lin ‐L You; Chien‐Jen ‐J Chen

doi:10.1002/1097-0142(19920415)69:8<2052::AID-CNCR2820690808>3.0.CO;2-N

The role of hepatitis B and C viruses in hepatocellular carcinoma in a hepatitis B endemic area. A case‐control study

Wan‐Long ‐L Chuang, Wen‐Yu ‐Y Chang^*, Sheng‐Nan ‐N Lu, Wang‐Pin ‐P Su, Zu‐Yau ‐Y Lin, Shinn‐Cherng ‐C Chen, Ming‐Yuh ‐Y Hsieh, Liang‐Yen ‐Y Wang, San‐Lin ‐L You, Chien‐Jen ‐J Chen

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

126 Scopus citations

Abstract

To investigate the role of hepatitis B (HBV) and C viruses (HCV) in hepatocellular carcinoma (HCC) in an HBV endemic area and elucidate the interaction of these two viruses, a case‐control study of 128 patients with HCC and 384 age‐matched and sex‐matched control subjects was done. The positive rates of hepatitis B surface antigen (HBsAg, 77.3%, 99 of 128) and anti‐HCV (19.5%, 25 of 128) in patients with HCC were significantly higher than in control subjects (P < 0.001). Both HBsAg and anti‐HCV were important risk factors for HCC (relative risks, 13.96 and 27.12, respectively), and the risk for HCC was elevated significantly to 40.05 (95% confidence interval, 12.57 to 127.6) when HBsAg and anti‐HCV were considered simultaneously. These results suggested that HBV and HCV were associated highly with HCC in an HBV endemic area and that these two viruses might contribute independent but synergistic effects to the pathogenesis of HCC.

Original language	English
Pages (from-to)	2052-2054
Number of pages	3
Journal	Cancer
Volume	69
Issue number	8
DOIs	https://doi.org/10.1002/1097-0142(19920415)69:8<2052::AID-CNCR2820690808>3.0.CO;2-N
State	Published - 15 04 1992
Externally published	Yes

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10.1002/1097-0142(19920415)69:8<2052::AID-CNCR2820690808>3.0.CO;2-N

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Chuang, WL. L., Chang, WY. Y., Lu, SN. N., Su, WP. P., Lin, ZY. Y., Chen, SC. C., Hsieh, MY. Y., Wang, LY. Y., You, SL. L., & Chen, CJ. J. (1992). The role of hepatitis B and C viruses in hepatocellular carcinoma in a hepatitis B endemic area. A case‐control study. Cancer, 69(8), 2052-2054. https://doi.org/10.1002/1097-0142(19920415)69:8<2052::AID-CNCR2820690808>3.0.CO;2-N

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abstract = "To investigate the role of hepatitis B (HBV) and C viruses (HCV) in hepatocellular carcinoma (HCC) in an HBV endemic area and elucidate the interaction of these two viruses, a case‐control study of 128 patients with HCC and 384 age‐matched and sex‐matched control subjects was done. The positive rates of hepatitis B surface antigen (HBsAg, 77.3%, 99 of 128) and anti‐HCV (19.5%, 25 of 128) in patients with HCC were significantly higher than in control subjects (P < 0.001). Both HBsAg and anti‐HCV were important risk factors for HCC (relative risks, 13.96 and 27.12, respectively), and the risk for HCC was elevated significantly to 40.05 (95% confidence interval, 12.57 to 127.6) when HBsAg and anti‐HCV were considered simultaneously. These results suggested that HBV and HCV were associated highly with HCC in an HBV endemic area and that these two viruses might contribute independent but synergistic effects to the pathogenesis of HCC.",

author = "Chuang, {Wan‐Long ‐L} and Chang, {Wen‐Yu ‐Y} and Lu, {Sheng‐Nan ‐N} and Su, {Wang‐Pin ‐P} and Lin, {Zu‐Yau ‐Y} and Chen, {Shinn‐Cherng ‐C} and Hsieh, {Ming‐Yuh ‐Y} and Wang, {Liang‐Yen ‐Y} and You, {San‐Lin ‐L} and Chen, {Chien‐Jen ‐J}",

year = "1992",

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doi = "10.1002/1097-0142(19920415)69:8<2052::AID-CNCR2820690808>3.0.CO;2-N",

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T1 - The role of hepatitis B and C viruses in hepatocellular carcinoma in a hepatitis B endemic area. A case‐control study

AU - Chuang, Wan‐Long ‐L

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AU - Su, Wang‐Pin ‐P

AU - Lin, Zu‐Yau ‐Y

AU - Chen, Shinn‐Cherng ‐C

AU - Hsieh, Ming‐Yuh ‐Y

AU - Wang, Liang‐Yen ‐Y

AU - You, San‐Lin ‐L

AU - Chen, Chien‐Jen ‐J

PY - 1992/4/15

Y1 - 1992/4/15

N2 - To investigate the role of hepatitis B (HBV) and C viruses (HCV) in hepatocellular carcinoma (HCC) in an HBV endemic area and elucidate the interaction of these two viruses, a case‐control study of 128 patients with HCC and 384 age‐matched and sex‐matched control subjects was done. The positive rates of hepatitis B surface antigen (HBsAg, 77.3%, 99 of 128) and anti‐HCV (19.5%, 25 of 128) in patients with HCC were significantly higher than in control subjects (P < 0.001). Both HBsAg and anti‐HCV were important risk factors for HCC (relative risks, 13.96 and 27.12, respectively), and the risk for HCC was elevated significantly to 40.05 (95% confidence interval, 12.57 to 127.6) when HBsAg and anti‐HCV were considered simultaneously. These results suggested that HBV and HCV were associated highly with HCC in an HBV endemic area and that these two viruses might contribute independent but synergistic effects to the pathogenesis of HCC.

AB - To investigate the role of hepatitis B (HBV) and C viruses (HCV) in hepatocellular carcinoma (HCC) in an HBV endemic area and elucidate the interaction of these two viruses, a case‐control study of 128 patients with HCC and 384 age‐matched and sex‐matched control subjects was done. The positive rates of hepatitis B surface antigen (HBsAg, 77.3%, 99 of 128) and anti‐HCV (19.5%, 25 of 128) in patients with HCC were significantly higher than in control subjects (P < 0.001). Both HBsAg and anti‐HCV were important risk factors for HCC (relative risks, 13.96 and 27.12, respectively), and the risk for HCC was elevated significantly to 40.05 (95% confidence interval, 12.57 to 127.6) when HBsAg and anti‐HCV were considered simultaneously. These results suggested that HBV and HCV were associated highly with HCC in an HBV endemic area and that these two viruses might contribute independent but synergistic effects to the pathogenesis of HCC.

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The role of hepatitis B and C viruses in hepatocellular carcinoma in a hepatitis B endemic area. A case‐control study

Abstract

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