The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis

Pei Hua Peng, Kai Wen Hsu, Joseph Chieh-Yu Lai, Kou Juey Wu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Long noncoding RNAs (lncRNAs) are noncoding RNAs with length greater than 200 nt. The biological roles and mechanisms mediated by lncRNAs have been extensively investigated. Hypoxia is a proven microenvironmental factor that promotes solid tumor metastasis. Epithelial-mesenchymal transition (EMT) is one of the major mechanisms induced by hypoxia to contribute to metastasis. Many lncRNAs have been shown to be induced by hypoxia and their roles have been delineated. In this review, we focus on the hypoxia-inducible lncRNAs that interact with protein/protein complex and chromatin/epigenetic factors, and the mechanisms that contribute to metastasis. The role of a recently discovered lncRNA RP11-390F4.3 in hypoxia-induced EMT is discussed. Whole genome approaches to delineating the association between lncRNAs and histone modifications are discussed. Other topics related to hypoxia-induced tumor progression but require further investigation are also mentioned. The clinical significance and treatment strategy targeted against lncRNAs are discussed. The review aims to identify suitable lncRNA targets that may provide feasible therapeutic venues for hypoxia-involved cancers.

Original languageEnglish
Pages (from-to)521-533
Number of pages13
JournalBiomedical Journal
Volume44
Issue number5
DOIs
StatePublished - 10 2021

Bibliographical note

Publisher Copyright:
© 2021 Chang Gung University

Keywords

  • Epigenetics
  • Epithelial–mesenchymal transition
  • Hypoxia
  • LncRNA RP11-390F4.3
  • Metastasis
  • lncRNAs

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