The role of NOD-like receptors in innate immunity

Cássio Luiz Coutinho Almeida-da-Silva*, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva, David M. Ojcius*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways that can rapidly initiate the host response against microbial infection and other sources of stress and danger. Research into the family of NOD-like receptors (NLRs) has blossomed over the past two decades, with much being learned about the ligands and conditions that stimulate the NLRs and the outcomes of NLR activation in cells and animals. The NLRs play key roles in diverse functions, ranging from transcription of MHC molecules to initiation of inflammation. Some NLRs are activated directly by their ligands, while other ligands may have indirect effects on the NLRs. New findings in coming years will undoubtedly shed more light on molecular details involved in NLR activation, as well as the physiological and immunological outcomes of NLR ligation.

Original languageEnglish
Article number1122586
Pages (from-to)1122586
JournalFrontiers in Immunology
StatePublished - 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2023 Almeida-da-Silva, Savio, Coutinho-Silva and Ojcius.


  • inflammasome
  • inflammation
  • innate immunity
  • nod-like receptors
  • pathogen recognition receptors
  • pathogen-associated molecular patterns
  • toll-like receptors
  • NLR Proteins
  • Inflammation
  • Immunity, Innate
  • Animals
  • Ligands
  • Carrier Proteins


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