The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats

Hua Chang Fang; Chien Liang Chen; Po Tsang Lee; Chih Yang Hsu; Ching Jiunn Tseng; Pei Jung Lu; Shung Lon Lai; Hsiao Min Chung; Kang Ju Chou

doi:10.1016/j.fct.2007.03.011

The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats

Hua Chang Fang, Chien Liang Chen, Po Tsang Lee, Chih Yang Hsu, Ching Jiunn Tseng, Pei Jung Lu, Shung Lon Lai, Hsiao Min Chung, Kang Ju Chou^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

15 Scopus citations

Abstract

To investigate the role of oxalate in star fruit neurotoxicity, rats were given star fruit or oxalate after a sham operation or modified five-sixths nephrectomy; namely, star fruit (SC) or oxalate (OxC) for sham-operated rats and star fruit (SNx), calcium gluconate treated star fruit juice (SCaNx), or oxalate (OxNx) for nephrectomized rats. After feedings, none of the rats in SC, OxC, and SCaNx groups developed movement disorders or died, while all rats in SNx group and OxNx group presented movement disorders and two rats in SNx group and four rats in OxNx group died within minute to hour after development of myoclonic jerk and/or tonic-clonic convulsion. The plasma oxalate levels rose significantly only in the SNx group and OxNx group that also presented clusters of generalized spike-waves in the electroencephalographic recordings. In conclusion, oxalate may play a key role in star fruit neurotoxicity in nephrectomized rats and probably in uremic patients.

Original language	English
Pages (from-to)	1764-1769
Number of pages	6
Journal	Food and Chemical Toxicology
Volume	45
Issue number	9
DOIs	https://doi.org/10.1016/j.fct.2007.03.011
State	Published - 09 2007
Externally published	Yes

Keywords

Neurotoxicity
Oxalate
Renal failure
Star fruit

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10.1016/j.fct.2007.03.011

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title = "The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats",

abstract = "To investigate the role of oxalate in star fruit neurotoxicity, rats were given star fruit or oxalate after a sham operation or modified five-sixths nephrectomy; namely, star fruit (SC) or oxalate (OxC) for sham-operated rats and star fruit (SNx), calcium gluconate treated star fruit juice (SCaNx), or oxalate (OxNx) for nephrectomized rats. After feedings, none of the rats in SC, OxC, and SCaNx groups developed movement disorders or died, while all rats in SNx group and OxNx group presented movement disorders and two rats in SNx group and four rats in OxNx group died within minute to hour after development of myoclonic jerk and/or tonic-clonic convulsion. The plasma oxalate levels rose significantly only in the SNx group and OxNx group that also presented clusters of generalized spike-waves in the electroencephalographic recordings. In conclusion, oxalate may play a key role in star fruit neurotoxicity in nephrectomized rats and probably in uremic patients.",

keywords = "Neurotoxicity, Oxalate, Renal failure, Star fruit",

author = "Fang, {Hua Chang} and Chen, {Chien Liang} and Lee, {Po Tsang} and Hsu, {Chih Yang} and Tseng, {Ching Jiunn} and Lu, {Pei Jung} and Lai, {Shung Lon} and Chung, {Hsiao Min} and Chou, {Kang Ju}",

year = "2007",

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doi = "10.1016/j.fct.2007.03.011",

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pages = "1764--1769",

journal = "Food and Chemical Toxicology",

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AU - Fang, Hua Chang

AU - Chen, Chien Liang

AU - Lee, Po Tsang

AU - Hsu, Chih Yang

AU - Tseng, Ching Jiunn

AU - Lu, Pei Jung

AU - Lai, Shung Lon

AU - Chung, Hsiao Min

AU - Chou, Kang Ju

PY - 2007/9

Y1 - 2007/9

N2 - To investigate the role of oxalate in star fruit neurotoxicity, rats were given star fruit or oxalate after a sham operation or modified five-sixths nephrectomy; namely, star fruit (SC) or oxalate (OxC) for sham-operated rats and star fruit (SNx), calcium gluconate treated star fruit juice (SCaNx), or oxalate (OxNx) for nephrectomized rats. After feedings, none of the rats in SC, OxC, and SCaNx groups developed movement disorders or died, while all rats in SNx group and OxNx group presented movement disorders and two rats in SNx group and four rats in OxNx group died within minute to hour after development of myoclonic jerk and/or tonic-clonic convulsion. The plasma oxalate levels rose significantly only in the SNx group and OxNx group that also presented clusters of generalized spike-waves in the electroencephalographic recordings. In conclusion, oxalate may play a key role in star fruit neurotoxicity in nephrectomized rats and probably in uremic patients.

AB - To investigate the role of oxalate in star fruit neurotoxicity, rats were given star fruit or oxalate after a sham operation or modified five-sixths nephrectomy; namely, star fruit (SC) or oxalate (OxC) for sham-operated rats and star fruit (SNx), calcium gluconate treated star fruit juice (SCaNx), or oxalate (OxNx) for nephrectomized rats. After feedings, none of the rats in SC, OxC, and SCaNx groups developed movement disorders or died, while all rats in SNx group and OxNx group presented movement disorders and two rats in SNx group and four rats in OxNx group died within minute to hour after development of myoclonic jerk and/or tonic-clonic convulsion. The plasma oxalate levels rose significantly only in the SNx group and OxNx group that also presented clusters of generalized spike-waves in the electroencephalographic recordings. In conclusion, oxalate may play a key role in star fruit neurotoxicity in nephrectomized rats and probably in uremic patients.

KW - Neurotoxicity

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KW - Renal failure

KW - Star fruit

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M3 - 文章

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JO - Food and Chemical Toxicology

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ER -

The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats

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