The roles of biomarkers of oxidative stress and antioxidant in alzheimer's disease: A systematic review

Ya Ting Chang; Wen Neng Chang; Nai Wen Tsai; Chih Cheng Huang; Chia Te Kung; Yu Jih Su; Wei Che Lin; Ben Chung Cheng; Chih Min Su; Yi Fang Chiang; Cheng Hsien Lu

doi:10.1155/2014/182303

The roles of biomarkers of oxidative stress and antioxidant in alzheimer's disease: A systematic review

Ya Ting Chang, Wen Neng Chang, Nai Wen Tsai, Chih Cheng Huang, Chia Te Kung, Yu Jih Su, Wei Che Lin, Ben Chung Cheng, Chih Min Su, Yi Fang Chiang, Cheng Hsien Lu^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Review article › peer-review

114 Scopus citations

Abstract

Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

Original language	English
Article number	182303
Journal	BioMed Research International
Volume	2014
DOIs	https://doi.org/10.1155/2014/182303
State	Published - 2014

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10.1155/2014/182303

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title = "The roles of biomarkers of oxidative stress and antioxidant in alzheimer's disease: A systematic review",

abstract = "Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.",

author = "Chang, {Ya Ting} and Chang, {Wen Neng} and Tsai, {Nai Wen} and Huang, {Chih Cheng} and Kung, {Chia Te} and Su, {Yu Jih} and Lin, {Wei Che} and Cheng, {Ben Chung} and Su, {Chih Min} and Chiang, {Yi Fang} and Lu, {Cheng Hsien}",

year = "2014",

doi = "10.1155/2014/182303",

language = "英语",

volume = "2014",

journal = "BioMed Research International",

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T1 - The roles of biomarkers of oxidative stress and antioxidant in alzheimer's disease

T2 - A systematic review

AU - Chang, Ya Ting

AU - Chang, Wen Neng

AU - Tsai, Nai Wen

AU - Huang, Chih Cheng

AU - Kung, Chia Te

AU - Su, Yu Jih

AU - Lin, Wei Che

AU - Cheng, Ben Chung

AU - Su, Chih Min

AU - Chiang, Yi Fang

AU - Lu, Cheng Hsien

PY - 2014

Y1 - 2014

N2 - Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

AB - Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

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U2 - 10.1155/2014/182303

DO - 10.1155/2014/182303

M3 - 文献综述

C2 - 24949424

AN - SCOPUS:84901779460

SN - 2314-6133

VL - 2014

JO - BioMed Research International

JF - BioMed Research International

M1 - 182303

ER -

The roles of biomarkers of oxidative stress and antioxidant in alzheimer's disease: A systematic review

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