The roles of the delta antigen in the structure and replication of hepatitis delta virus

John Taylor; Mel Chao; Sen Yung Hsieh; Ryu Wang-Shick

doi:10.1016/0168-8278(91)90041-9

The roles of the delta antigen in the structure and replication of hepatitis delta virus

John Taylor^*, Mel Chao, Sen Yung Hsieh, Ryu Wang-Shick

^*Corresponding author for this work

Fox Chase Cancer Center

Research output: Contribution to journal › Journal Article › peer-review

8 Scopus citations

Abstract

The delta antigen is the only known protein encoded by hepatitis delta virus (HDV). The predicted protein is 195 amino acids in length, but for reasons that are not yet clear, there occurs during the replication of the HDV genome, a specific base change in the termination codon of this open reading frame. This leads to the synthesis of a form of the delta antigen that is 19 amino acids longer, with a total length of 214 amino acids. Studies are described which relate to the roles of these two forms of the delta antigen in genome replication and subsequent particle assembly.

Original language	English
Pages (from-to)	S119-S120
Journal	Journal of Hepatology
Volume	13
Issue number	SUPPL. 4
DOIs	https://doi.org/10.1016/0168-8278(91)90041-9
State	Published - 1991
Externally published	Yes

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10.1016/0168-8278(91)90041-9

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abstract = "The delta antigen is the only known protein encoded by hepatitis delta virus (HDV). The predicted protein is 195 amino acids in length, but for reasons that are not yet clear, there occurs during the replication of the HDV genome, a specific base change in the termination codon of this open reading frame. This leads to the synthesis of a form of the delta antigen that is 19 amino acids longer, with a total length of 214 amino acids. Studies are described which relate to the roles of these two forms of the delta antigen in genome replication and subsequent particle assembly.",

author = "John Taylor and Mel Chao and Hsieh, {Sen Yung} and Ryu Wang-Shick",

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AU - Chao, Mel

AU - Hsieh, Sen Yung

AU - Wang-Shick, Ryu

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AB - The delta antigen is the only known protein encoded by hepatitis delta virus (HDV). The predicted protein is 195 amino acids in length, but for reasons that are not yet clear, there occurs during the replication of the HDV genome, a specific base change in the termination codon of this open reading frame. This leads to the synthesis of a form of the delta antigen that is 19 amino acids longer, with a total length of 214 amino acids. Studies are described which relate to the roles of these two forms of the delta antigen in genome replication and subsequent particle assembly.

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IS - SUPPL. 4

ER -

The roles of the delta antigen in the structure and replication of hepatitis delta virus

Abstract

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