The status of serum hepatitis B virus DNA in HBSAG-positive hepatocellular carcinoma.

M. L. Yu; W. L. Chuang; T. Y. Chow; S. C. Chen; S. N. Lu; Z. Y. Lin; M. Y. Hsieh; L. Y. Wang; W. Y. Chang

The status of serum hepatitis B virus DNA in HBSAG-positive hepatocellular carcinoma.

M. L. Yu^*, W. L. Chuang, T. Y. Chow, S. C. Chen, S. N. Lu, Z. Y. Lin, M. Y. Hsieh, L. Y. Wang, W. Y. Chang

^*Corresponding author for this work

Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

To elucidate the status of serum hepatitis B virus (HBV) DNA in HBsAg-positive hepatocellular carcinoma (HCC), 100 type B chronic liver disease (CLD) patients and 19 HCC patients were studied. The positive rate of serum HBV DNA in HBeAg-positive CLD patients was significantly higher than that in HBeAg-negative CLD patients, and the correlation between the presence of serum HBV DNA and patients' age showed a negative trend. In contrast, the positive rates of serum HBV DNA in HCC patients were not related to the status of HBeAg and age, and the positive rate of serum HBV DNA in HBeAg-negative HCC patients was significantly higher than that in HBeAg-negative CLD patients. Nevertheless, the serum concentrations of HBV DNA in HCC patients were significantly lower than those in CLD patients. These results suggest that replication of HBV in HCC patients might differ from that in CLD patients, and that persistent low-level HBV replication might be related to the presence of HCC.

Original language	English
Pages (from-to)	466-470
Number of pages	5
Journal	Kaohsiung Journal of Medical Sciences
Volume	12
Issue number	8
State	Published - 08 1996
Externally published	Yes

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title = "The status of serum hepatitis B virus DNA in HBSAG-positive hepatocellular carcinoma.",

abstract = "To elucidate the status of serum hepatitis B virus (HBV) DNA in HBsAg-positive hepatocellular carcinoma (HCC), 100 type B chronic liver disease (CLD) patients and 19 HCC patients were studied. The positive rate of serum HBV DNA in HBeAg-positive CLD patients was significantly higher than that in HBeAg-negative CLD patients, and the correlation between the presence of serum HBV DNA and patients' age showed a negative trend. In contrast, the positive rates of serum HBV DNA in HCC patients were not related to the status of HBeAg and age, and the positive rate of serum HBV DNA in HBeAg-negative HCC patients was significantly higher than that in HBeAg-negative CLD patients. Nevertheless, the serum concentrations of HBV DNA in HCC patients were significantly lower than those in CLD patients. These results suggest that replication of HBV in HCC patients might differ from that in CLD patients, and that persistent low-level HBV replication might be related to the presence of HCC.",

author = "Yu, {M. L.} and Chuang, {W. L.} and Chow, {T. Y.} and Chen, {S. C.} and Lu, {S. N.} and Lin, {Z. Y.} and Hsieh, {M. Y.} and Wang, {L. Y.} and Chang, {W. Y.}",

year = "1996",

month = aug,

language = "英语",

volume = "12",

pages = "466--470",

journal = "Kaohsiung Journal of Medical Sciences",

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T1 - The status of serum hepatitis B virus DNA in HBSAG-positive hepatocellular carcinoma.

AU - Yu, M. L.

AU - Chuang, W. L.

AU - Chow, T. Y.

AU - Chen, S. C.

AU - Lu, S. N.

AU - Lin, Z. Y.

AU - Hsieh, M. Y.

AU - Wang, L. Y.

AU - Chang, W. Y.

PY - 1996/8

Y1 - 1996/8

N2 - To elucidate the status of serum hepatitis B virus (HBV) DNA in HBsAg-positive hepatocellular carcinoma (HCC), 100 type B chronic liver disease (CLD) patients and 19 HCC patients were studied. The positive rate of serum HBV DNA in HBeAg-positive CLD patients was significantly higher than that in HBeAg-negative CLD patients, and the correlation between the presence of serum HBV DNA and patients' age showed a negative trend. In contrast, the positive rates of serum HBV DNA in HCC patients were not related to the status of HBeAg and age, and the positive rate of serum HBV DNA in HBeAg-negative HCC patients was significantly higher than that in HBeAg-negative CLD patients. Nevertheless, the serum concentrations of HBV DNA in HCC patients were significantly lower than those in CLD patients. These results suggest that replication of HBV in HCC patients might differ from that in CLD patients, and that persistent low-level HBV replication might be related to the presence of HCC.

AB - To elucidate the status of serum hepatitis B virus (HBV) DNA in HBsAg-positive hepatocellular carcinoma (HCC), 100 type B chronic liver disease (CLD) patients and 19 HCC patients were studied. The positive rate of serum HBV DNA in HBeAg-positive CLD patients was significantly higher than that in HBeAg-negative CLD patients, and the correlation between the presence of serum HBV DNA and patients' age showed a negative trend. In contrast, the positive rates of serum HBV DNA in HCC patients were not related to the status of HBeAg and age, and the positive rate of serum HBV DNA in HBeAg-negative HCC patients was significantly higher than that in HBeAg-negative CLD patients. Nevertheless, the serum concentrations of HBV DNA in HCC patients were significantly lower than those in CLD patients. These results suggest that replication of HBV in HCC patients might differ from that in CLD patients, and that persistent low-level HBV replication might be related to the presence of HCC.

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M3 - 文章

C2 - 8774115

AN - SCOPUS:0030210445

SN - 1607-551X

VL - 12

SP - 466

EP - 470

JO - Kaohsiung Journal of Medical Sciences

JF - Kaohsiung Journal of Medical Sciences

IS - 8

ER -

The status of serum hepatitis B virus DNA in HBSAG-positive hepatocellular carcinoma.

Abstract

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