The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

Sebastian J. Arnold; Guo Jen Huang; Amanda F.P. Cheung; Takumi Era; Shin Ichi Nishikawa; Elizabeth K. Bikoff; Zoltán Molnár; Elizabeth J. Robertson; Matthias Groszer

doi:10.1101/gad.475408

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

Sebastian J. Arnold, Guo Jen Huang, Amanda F.P. Cheung, Takumi Era, Shin Ichi Nishikawa, Elizabeth K. Bikoff, Zoltán Molnár, Elizabeth J. Robertson, Matthias Groszer^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

272 Scopus citations

Abstract

The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are largely unknown. The transcription factor Eomes/Tbr2 is transiently expressed in cortical SVZ progenitor cells. Here we demonstrate that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits. In Tbr2 mutants the number of SVZ progenitor cells is reduced and the differentiation of upper cortical layer neurons is disturbed. Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ.

Original language	English
Pages (from-to)	2479-2484
Number of pages	6
Journal	Genes and Development
Volume	22
Issue number	18
DOIs	https://doi.org/10.1101/gad.475408
State	Published - 15 09 2008
Externally published	Yes

Keywords

Brain size
Eomesodermin
Neuronal progenitor cells
SVZ
Tbr2

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title = "The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone",

abstract = "The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are largely unknown. The transcription factor Eomes/Tbr2 is transiently expressed in cortical SVZ progenitor cells. Here we demonstrate that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits. In Tbr2 mutants the number of SVZ progenitor cells is reduced and the differentiation of upper cortical layer neurons is disturbed. Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ.",

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AU - Arnold, Sebastian J.

AU - Huang, Guo Jen

AU - Cheung, Amanda F.P.

AU - Era, Takumi

AU - Nishikawa, Shin Ichi

AU - Bikoff, Elizabeth K.

AU - Molnár, Zoltán

AU - Robertson, Elizabeth J.

AU - Groszer, Matthias

PY - 2008/9/15

Y1 - 2008/9/15

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AB - The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are largely unknown. The transcription factor Eomes/Tbr2 is transiently expressed in cortical SVZ progenitor cells. Here we demonstrate that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits. In Tbr2 mutants the number of SVZ progenitor cells is reduced and the differentiation of upper cortical layer neurons is disturbed. Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ.

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KW - Neuronal progenitor cells

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KW - Tbr2

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The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

Abstract

Keywords

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