The TNF2 allele does not contribute towards susceptibility to systemic lupus erythematosus

Chung Jen Chen, Jeng Hsien Yen, Wen Chan Tsai, Ching Shiuan Wu, Wen Chiang, Jih Jin Tsai, Hong Wen Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

35 Scopus citations

Abstract

The uncommon allele (TNF2) of a polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-α) gene has been reported to be increased in Caucasian systemic lupus erythematosus (SLE) patients (associated with HLA-DR3). To investigate whether TNF2 contributes towards susceptibility to Chinese SLE patients (not associated with HLA-DR3), 100 patients with SLE and 107 controls were studied. The frequency of TNF2 allele in controls was 0.140. There was a strong association between TNF2 allele and HLA-DR3 (P < 10-8) in controls. The frequency of TNF2 allele in SLE patients was 0.15. There was no difference in frequencies of TNF2 allele between patients and controls. This finding strongly suggests that TNF2 does not play a direct role in the susceptibility of SLE.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalImmunology Letters
Volume55
Issue number1
DOIs
StatePublished - 01 1997
Externally publishedYes

Keywords

  • Systemic lupus erythematosus
  • TNF2
  • Tumor necrosis factor

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