The utility F-box for protein destruction

M. S. Ho, C. Ou, Y. R. Chan, C. T. Chien*, H. Pi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


A signature feature of all living organisms is their utilization of proteins to construct molecular machineries that undertake the complex network of cellular activities. The abundance of a protein element is temporally and spatially regulated in two opposing aspects: de novo synthesis to manufacture the required amount of the protein, and destruction of the protein when it is in excess or no longer needed. One major route of protein destruction is coordinated by a set of conserved molecules, the F-box proteins, which promote ubiquitination in the ubiquitin-proteasome pathway. Here we discuss the functions of F-box proteins in several cellular scenarios including cell cycle progression, synapse formation, plant hormone responses, and the circadian clock. We particularly emphasize the mechanisms whereby F-box proteins recruit specific substrates and regulate their abundance in the context of SCF E3 ligases. For some exceptions, we also review how F-box proteins function through non-SCF mechanisms.

Original languageEnglish
Pages (from-to)1977-2000
Number of pages24
JournalCellular and Molecular Life Sciences
Issue number13
StatePublished - 07 2008


  • 26S proteasome
  • F-box
  • Protein degradation
  • SCF
  • Ubiquitination


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