The value of time-averaged serum high-sensitivity c-reactive protein in prediction of mortality and dropout in peritoneal dialysis patients

Shou Hsuan Liu, Chao Yu Chen, Yi Jung Li, Hsin Hsu Wu, Chan Yu Lin, Yung Chang Chen, Ming Yang Chang, Hsiang Hao Hsu, Cheng Lung Ku, Ya Chung Tian*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations

Abstract

Purpose: C-reactive protein (CRP) is a useful biomarker for prediction of long-term outcomes in patients undergoing chronic dialysis. This observational cohort study evaluated whether the time-averaged serum high-sensitivity CRP (HS-CRP) level was a better predictor of clinical outcomes than a single HS-CRP level in patients undergoing peritoneal dialysis (PD). Patients and methods: We classified 335 patients into three tertiles according to the time-averaged serum HS-CRP level and followed up regularly from January 2010 to December 2014. Clinical outcomes such as cardiovascular events, infection episodes, newly developed malignancy, encapsulating peritoneal sclerosis (EPS), dropout (death plus conversion to hemodialysis), and mortality were assessed. Results: During a 5-year follow-up, 164 patients (49.0%) ceased PD; this included 52 patient deaths (15.5%), 100 patients (29.9%) who converted to hemodialysis, and 12 patients (3.6%) who received a kidney transplantation. The Kaplan–Meier survival analysis and log-rank test revealed a significantly worse survival accumulation in patients with high time-average HS-CRP levels. A multivariate Cox regression analysis revealed that a higher time-averaged serum HS-CRP level, older age, and the occurrence of cardiovascular events were independent mortality predictors. A higher time-averaged serum HS-CRP level, the occurrence of cardiovascular events, infection episodes, and EPS were important predictors of dropout. The receiver operating characteristic analysis verified that the value of the time-average HS-CRP level in predicting the 5-year mortality and dropout was superior to a single serum baseline HS-CRP level. Conclusion: This study shows that the time-averaged serum HS-CRP level is a better marker than a single baseline measurement in predicting the 5-year mortality and dropout in PD patients.

Original languageEnglish
Pages (from-to)1009-1021
Number of pages13
JournalTherapeutics and Clinical Risk Management
Volume13
DOIs
StatePublished - 16 08 2017

Bibliographical note

Publisher Copyright:
© 2017 Liu et al.

Keywords

  • Dropout
  • Encapsulating peritoneal sclerosis
  • High sensitivity C-reactive protein
  • Malignancy
  • Mortality
  • Peritoneal dialysis

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