Therapeutic hypothermia for febrile infection-related epilepsy syndrome in two patients

Jainn Jim Lin, Kuang Lin Lin*, Shao Hsuan Hsia, Huei Shyong Wang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

51 Scopus citations


Despite advances in critical care, febrile infection-related epilepsy syndrome remains the most important cause of mortality and neurologic deficits during childhood. Only a few therapeutic agents were reported to shorten the acute phase and improve outcomes. Therapeutic hypothermia was reported effective in stabilizing immune activation, brain edema, and seizure activity, to protect the brain from ongoing functional, apoptotic neural, and glial damage and the systemic expansion of the cytokine storm. We present two pediatric cases of febrile infection-related epilepsy syndrome, refractory to conventional medical therapy. Moderate therapeutic hypothermia at 33°C resulted in fast, sustained control of refractory status epilepticus. After 3 months, both patients recovered with a Glasgow Outcome Scale score of 4. Therapeutic hypothermia may play an important role in children with febrile infection-related epilepsy syndrome.

Original languageEnglish
Pages (from-to)448-450
Number of pages3
JournalPediatric Neurology
Issue number6
StatePublished - 12 2012


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