Thermo-sensitive injectable hydrogels as synthetic extracellular matrices for hepatocyte culture

H. C. Chen*, J. P. Chen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The behavior of freshly isolated rat hepatosites cultivated within an injectable thermo-sensitive hydrogel based on N-isopropylacrylamide was investigated. It was observed that the hepatocytes preserved mitochondrial functionality for up to a week. The hepatocytes attachment to galactose-modified hydrogel was enhanced due to specific cell-ligand interactions. The results suggested that galactose-modified hydrogels can be used as an injectable scaffold for hepatic tissue engineering applications.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1062
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 05 200421 05 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Conference

ConferenceTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period17/05/0421/05/04

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