Thermoplastic polyurethane/hydroxyapatite electrospun scaffolds for bone tissue engineering: Effects of polymer properties and particle size

Hao Yang Mi, Sun Mi Palumbo, Xin Jing, Lih Sheng Turng*, Wan Ju Li, Xiang Fang Peng

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

80 Scopus citations

Abstract

Thermoplastic polyurethane (TPU)/hydroxyapatite (HA) scaffolds were fabricated via electrospinning. The effects of TPU properties and HA particle size on scaffold physical properties and osteoblast-like cell performance were investigated. It was found that the addition of micro-HA (mHA), which was inlayed in the fiber, decreased the electrospun fiber diameter. On the contrary, nano-HA (nHA), which was either embedded or existed inside of the fiber, increased the fiber diameter for both soft and hard TPUs. The soft TPU had a much lower Young's modulus and higher strain-at-break than the hard TPU. The addition of both mHA and nHA decreased the tensile properties; this decrease was more significant with mHA. The cells on the hard scaffolds actively proliferated and migrated compared to those on the soft scaffolds. On the other hand, cells on the soft scaffolds more effectively induced osteogenesis of human mesenchymal stem cells (hMSCs) than those on the hard scaffolds. In addition, our data suggest that the soft scaffolds with supplementation of nHA further enhanced osteogenesis of hMSCs compared to those without nHA. The soft TPU scaffolds containing nano-HA have the potential to be used in bone tissue engineering applications.

Original languageEnglish
Pages (from-to)1434-1444
Number of pages11
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume102
Issue number7
DOIs
StatePublished - 01 10 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
©2014 Wiley Periodicals, Inc.

Keywords

  • Bone tissue scaffolds
  • Electrospinning
  • Hydroxyapatite
  • Thermoplastic polyurethane

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