Thermoplastic polyurethane/polylactic acid tissue scaffold fabricated by twin screw extrusion and microcellular injection molding

Hao Yang Mi, Xin Jing, Brianna Jacques, Lih Sheng Turng*, Xiang Fang Peng

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Polylactic acid (PLA) and thermoplastic polyurethane (TPU) are two kinds of biocompatible and biodegradable polymers that can be used in biomedical applications. They possess rigid and flexible mechanical properties. The TPU/PLA blend tissue scaffolds at different ratios were fabricated via twin screw extrusion and micro-cellular injection molding techniques (a. k. a. MuCell) for the first time. Multiple test methods were used in this study. Fourier transform infrared spectroscopy (FTIR) verified the presence of the two components in the blends. Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) confirmed the immiscibility between TPU and PLA. Scanning electron microscopy (SEM) images affirmed that the PLA was dispersed as spheres or islands inside the TPU matrix, and that the phase morphology further influenced the surface roughness of cells. The blends exhibited a wide range of mechanical properties that cover most human tissue requirements. It was found from DMA and viscosity tests that 25% PLA significantly reinforces the blends at low temperatures or deformation frequencies.

Original languageEnglish
Title of host publication71st Annual Technical Conference of the Society of Plastics Engineers 2013, ANTEC 2013
PublisherSociety of Plastics Engineers
Pages1610-1614
Number of pages5
ISBN (Print)9781632665300
StatePublished - 2013
Externally publishedYes
Event71st Annual Technical Conference of the Society of Plastics Engineers 2013, ANTEC 2013 - Cincinnati, OH, United States
Duration: 22 04 201324 04 2013

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume2

Conference

Conference71st Annual Technical Conference of the Society of Plastics Engineers 2013, ANTEC 2013
Country/TerritoryUnited States
CityCincinnati, OH
Period22/04/1324/04/13

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