Abstract
Irinotecan, sold under the brand name Camptosar (CPT-11), can be used as a brain cancer medication. In current cancer therapies, an important problem in the treatment of cancer is in short of selective targeting, which can damage healthy tissues while only killing cancer cells minimally. Therefore, innovative targeting strategies designed to increase cancer selectivity while preventing or minimizing accumulation in healthy tissues are needed. The anti-epidermal growth factor receptor (EGFR) monoclonal antibody, cetuximab (CET), specifically binds the EGFR with a high affinity. The EGFR is concomitantly over-expressed by most brain tumors, but not by normal tissues. Ligand-mediated targeting could improve both biodistribution and tumor accumulation of chemotherapeutic nanodrugs to result in higher therapeutic efficacy. Accumulation of a drug within the brain tumor environment could be also achieved by external magnetic field-induced guidance technology where an external magnetic field placed near the brain tumor attracts a magneticfluidloaded liposomal system after intravenous administration. Additionally, magnetic nanoparticles (MNPs) loaded into thermosensitive liposomes can transform electromagnetic energy from an external high-frequency field into a source of heat. This ability to create heat under this proposed alternating magnetic field (AMF) makes magnetic nanomaterials a supreme heat source for biomedical uses such as cancer thermo-ablative treatment and remote control of drug release. In this study, we engineered a multifunctional drug delivery system for the treatment of brain cancer by combining magnetic features with ligand-mediated and thermal-triggered drug release features.
Original language | English |
---|---|
Title of host publication | Society for Biomaterials Annual Meeting and Exposition 2019 |
Subtitle of host publication | The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting |
Publisher | Society for Biomaterials |
Pages | 54 |
Number of pages | 1 |
ISBN (Electronic) | 9781510883901 |
State | Published - 2019 |
Event | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: 03 04 2019 → 06 04 2019 |
Publication series
Name | Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium |
---|---|
Volume | 40 |
ISSN (Print) | 1526-7547 |
Conference
Conference | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence |
---|---|
Country/Territory | United States |
City | Seattle |
Period | 03/04/19 → 06/04/19 |
Bibliographical note
Publisher Copyright:© 2019 Omnipress - All rights reserved.