Thrombopoietin and the hematopoietic stem cell

Kenneth Kaushansky

doi:10.1196/annals.1349.018

Thrombopoietin and the hematopoietic stem cell

Kenneth Kaushansky^*

^*Corresponding author for this work

University of California at San Diego

Research output: Contribution to journal › Journal Article › peer-review

55 Scopus citations

Abstract

The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self-renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways. We found that TPO enhances the transcription of HoxB4, induces the nuclear localization of HoxA9, and upregulates VEGF expression by reducing the ubiquination of hypoxia inducible factor.

Original language	English
Pages (from-to)	139-141
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1044
DOIs	https://doi.org/10.1196/annals.1349.018
State	Published - 2005
Externally published	Yes

Keywords

Hematopoietic stem cells
Hox genes
Thrombopoietin

Access to Document

10.1196/annals.1349.018

Cite this

@article{7cebcd9b731848febb25886b54959bde,

title = "Thrombopoietin and the hematopoietic stem cell",

abstract = "The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self-renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways. We found that TPO enhances the transcription of HoxB4, induces the nuclear localization of HoxA9, and upregulates VEGF expression by reducing the ubiquination of hypoxia inducible factor.",

keywords = "Hematopoietic stem cells, Hox genes, Thrombopoietin",

author = "Kenneth Kaushansky",

year = "2005",

doi = "10.1196/annals.1349.018",

language = "英语",

volume = "1044",

pages = "139--141",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc",

}

TY - JOUR

T1 - Thrombopoietin and the hematopoietic stem cell

AU - Kaushansky, Kenneth

PY - 2005

Y1 - 2005

N2 - The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self-renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways. We found that TPO enhances the transcription of HoxB4, induces the nuclear localization of HoxA9, and upregulates VEGF expression by reducing the ubiquination of hypoxia inducible factor.

AB - The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self-renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways. We found that TPO enhances the transcription of HoxB4, induces the nuclear localization of HoxA9, and upregulates VEGF expression by reducing the ubiquination of hypoxia inducible factor.

KW - Hematopoietic stem cells

KW - Hox genes

KW - Thrombopoietin

UR - http://www.scopus.com/inward/record.url?scp=22044447126&partnerID=8YFLogxK

U2 - 10.1196/annals.1349.018

DO - 10.1196/annals.1349.018

M3 - 文章

C2 - 15958707

AN - SCOPUS:22044447126

SN - 0077-8923

VL - 1044

SP - 139

EP - 141

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Thrombopoietin and the hematopoietic stem cell

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this