Thrombopoietin in normal and neoplastic stem cell development

Kenneth Kaushansky; Helen M. Ranney

doi:10.1016/j.beha.2009.08.004

Thrombopoietin in normal and neoplastic stem cell development

Kenneth Kaushansky, Helen M. Ranney^*

^*Corresponding author for this work

University of California at San Diego

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V₆₁₇F.

Original language	English
Pages (from-to)	495-499
Number of pages	5
Journal	Best Practice and Research: Clinical Haematology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.beha.2009.08.004
State	Published - 12 2009
Externally published	Yes

Keywords

c-MPL
HOX
JAK2
myeloproliferative disorders
stem cell
thrombopoietin

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10.1016/j.beha.2009.08.004

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title = "Thrombopoietin in normal and neoplastic stem cell development",

abstract = "It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V617F.",

keywords = "c-MPL, HOX, JAK2, myeloproliferative disorders, stem cell, thrombopoietin",

author = "Kenneth Kaushansky and Ranney, {Helen M.}",

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volume = "22",

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T1 - Thrombopoietin in normal and neoplastic stem cell development

AU - Kaushansky, Kenneth

AU - Ranney, Helen M.

PY - 2009/12

Y1 - 2009/12

N2 - It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V617F.

AB - It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V617F.

KW - c-MPL

KW - HOX

KW - JAK2

KW - myeloproliferative disorders

KW - stem cell

KW - thrombopoietin

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U2 - 10.1016/j.beha.2009.08.004

DO - 10.1016/j.beha.2009.08.004

M3 - 文献综述

C2 - 19959099

AN - SCOPUS:71749092866

SN - 1521-6926

VL - 22

SP - 495

EP - 499

JO - Best Practice and Research: Clinical Haematology

JF - Best Practice and Research: Clinical Haematology

IS - 4

ER -

Thrombopoietin in normal and neoplastic stem cell development

Abstract

Keywords

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