TY - JOUR
T1 - Thymol, benzofuranoid, and phenylpropanoid derivatives
T2 - Anti-inflammatory constituents from Eupatorium cannabinum
AU - Chen, Jih Jung
AU - Tsai, Yun Chen
AU - Hwang, Tsong Long
AU - Wang, Tai Chi
PY - 2011/5/27
Y1 - 2011/5/27
N2 - Five new compounds, 9-O-angeloyl-8,10-dehydrothymol (1), 9-(3-methylbutanoyl)-8,10-dehydrothymol (2), eupatobenzofuran (3), 2-hydroxy-2,6-dimethylbenzofuran-3(2H)-one (4), and 1-(2-hydroxy-4-methylphenyl) propan-1,2-dione (5), have been isolated from the aerial part of Eupatorium cannabinum subsp. asiaticum, together with 16 known compounds (6-21). Compounds 6-8, 11, 13, and 15 exhibited inhibition (IC50 values ≤ 18.4 μM) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 2, 3, 10, 13, and 15 inhibited fMLP/CB-induced elastase release with IC 50 values ≤ 18.3 μM. (Chemical Equation Presented).
AB - Five new compounds, 9-O-angeloyl-8,10-dehydrothymol (1), 9-(3-methylbutanoyl)-8,10-dehydrothymol (2), eupatobenzofuran (3), 2-hydroxy-2,6-dimethylbenzofuran-3(2H)-one (4), and 1-(2-hydroxy-4-methylphenyl) propan-1,2-dione (5), have been isolated from the aerial part of Eupatorium cannabinum subsp. asiaticum, together with 16 known compounds (6-21). Compounds 6-8, 11, 13, and 15 exhibited inhibition (IC50 values ≤ 18.4 μM) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 2, 3, 10, 13, and 15 inhibited fMLP/CB-induced elastase release with IC 50 values ≤ 18.3 μM. (Chemical Equation Presented).
UR - https://www.scopus.com/pages/publications/79957854000
U2 - 10.1021/np100923z
DO - 10.1021/np100923z
M3 - 文章
C2 - 21391659
AN - SCOPUS:79957854000
SN - 0163-3864
VL - 74
SP - 1021
EP - 1027
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -