Ti-6al-4v Intervertebral Fusion Cage with Compatible Stiffness, Enhanced Fatigue Life, and Osteogenic Differentiation

Yu-Jie Wu; Chi-Yun Wang; Kuei-Chih Feng; R.R. Chien; Haidee Mana-Ay; Shyang-Yih Kung; Kuang-Hua Hou; Chi-Shun Tu; Pin-Yi Chen; Po-Liang Lai

doi:10.2139/ssrn.4367770

Ti-6al-4v Intervertebral Fusion Cage with Compatible Stiffness, Enhanced Fatigue Life, and Osteogenic Differentiation

Yu-Jie Wu, Chi-Yun Wang, Kuei-Chih Feng, R.R. Chien, Haidee Mana-Ay, Shyang-Yih Kung, Kuang-Hua Hou, Chi-Shun Tu, Pin-Yi Chen, Po-Liang Lai

Research output: Contribution to journal › Journal Article › peer-review

Abstract

<div data-language="eng" data-ev-field="abstract">The 3D-printed Ti-6Al-4V intervertebral fusion cage is fabricated to be biocompatible with improved stiffness, fatigue life, and osteogenic differentiation, which are greatly enhanced by heat treatment and surface modification. The flexible cage’s life, which exceeds the standard dynamic fatigue requirement of 5x106 cycles based on the ASTM F2077 and F2267 test methods, is achieved by heat treatment at 800 ℃ in argon atmosphere, shot peening, and adjusting the α to β phase ratio to increase mechanical toughness. Surface modification via sandblasting and chemical etching removes the surface oxide layer and forms submicron pores on the surface of the cage, which significantly boosts cell proliferation, differentiation, and osteoblast mineralization. This work exhibits a novel design of Ti-6Al-4V intervertebral fusion cage with biocompatible stiffness, enhanced fatigue life, and improved osteogenic differentiation achieved by reducing residual stress, modifying surface micro-pores, and optimizing microstructure.<br/></div> © 2023, The Authors. All rights reserved.

Original language	American English
Journal	SSRN
DOIs	https://doi.org/10.2139/ssrn.4367770
State	Published - 2023

Keywords

3D printing
Biocompatibility
Cell proliferation
Chemical modification
Etching
Fatigue testing
Residual stresses
Shot peening
Stiffness
Ternary alloys
Titanium alloys
Vanadium alloys
3-D printing
3D-printing
Dynamic fatigue
Enhanced fatigue lives
Fusion cages
Intervertebral spine cage
Osteogenic differentiation
Surface-modification
Ti-6al-4v

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10.2139/ssrn.4367770

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@article{d9aef20aa2404eed9ffc4dddc0c97d1f,

title = "Ti-6al-4v Intervertebral Fusion Cage with Compatible Stiffness, Enhanced Fatigue Life, and Osteogenic Differentiation",

abstract = "The 3D-printed Ti-6Al-4V intervertebral fusion cage is fabricated to be biocompatible with improved stiffness, fatigue life, and osteogenic differentiation, which are greatly enhanced by heat treatment and surface modification. The flexible cage’s life, which exceeds the standard dynamic fatigue requirement of 5x106 cycles based on the ASTM F2077 and F2267 test methods, is achieved by heat treatment at 800 ℃ in argon atmosphere, shot peening, and adjusting the α to β phase ratio to increase mechanical toughness. Surface modification via sandblasting and chemical etching removes the surface oxide layer and forms submicron pores on the surface of the cage, which significantly boosts cell proliferation, differentiation, and osteoblast mineralization. This work exhibits a novel design of Ti-6Al-4V intervertebral fusion cage with biocompatible stiffness, enhanced fatigue life, and improved osteogenic differentiation achieved by reducing residual stress, modifying surface micro-pores, and optimizing microstructure. © 2023, The Authors. All rights reserved.",

keywords = "3D printing, Biocompatibility, Cell proliferation, Chemical modification, Etching, Fatigue testing, Residual stresses, Shot peening, Stiffness, Ternary alloys, Titanium alloys, Vanadium alloys, 3-D printing, 3D-printing, Dynamic fatigue, Enhanced fatigue lives, Fusion cages, Intervertebral spine cage, Osteogenic differentiation, Surface-modification, Ti-6al-4v",

author = "Yu-Jie Wu and Chi-Yun Wang and Kuei-Chih Feng and R.R. Chien and Haidee Mana-Ay and Shyang-Yih Kung and Kuang-Hua Hou and Chi-Shun Tu and Pin-Yi Chen and Po-Liang Lai",

year = "2023",

doi = "10.2139/ssrn.4367770",

language = "American English",

journal = "SSRN",

issn = "1556-5068",

}

TY - JOUR

T1 - Ti-6al-4v Intervertebral Fusion Cage with Compatible Stiffness, Enhanced Fatigue Life, and Osteogenic Differentiation

AU - Wu, Yu-Jie

AU - Wang, Chi-Yun

AU - Feng, Kuei-Chih

AU - Chien, R.R.

AU - Mana-Ay, Haidee

AU - Kung, Shyang-Yih

AU - Hou, Kuang-Hua

AU - Tu, Chi-Shun

AU - Chen, Pin-Yi

AU - Lai, Po-Liang

PY - 2023

Y1 - 2023

N2 - The 3D-printed Ti-6Al-4V intervertebral fusion cage is fabricated to be biocompatible with improved stiffness, fatigue life, and osteogenic differentiation, which are greatly enhanced by heat treatment and surface modification. The flexible cage’s life, which exceeds the standard dynamic fatigue requirement of 5x106 cycles based on the ASTM F2077 and F2267 test methods, is achieved by heat treatment at 800 ℃ in argon atmosphere, shot peening, and adjusting the α to β phase ratio to increase mechanical toughness. Surface modification via sandblasting and chemical etching removes the surface oxide layer and forms submicron pores on the surface of the cage, which significantly boosts cell proliferation, differentiation, and osteoblast mineralization. This work exhibits a novel design of Ti-6Al-4V intervertebral fusion cage with biocompatible stiffness, enhanced fatigue life, and improved osteogenic differentiation achieved by reducing residual stress, modifying surface micro-pores, and optimizing microstructure. © 2023, The Authors. All rights reserved.

AB - The 3D-printed Ti-6Al-4V intervertebral fusion cage is fabricated to be biocompatible with improved stiffness, fatigue life, and osteogenic differentiation, which are greatly enhanced by heat treatment and surface modification. The flexible cage’s life, which exceeds the standard dynamic fatigue requirement of 5x106 cycles based on the ASTM F2077 and F2267 test methods, is achieved by heat treatment at 800 ℃ in argon atmosphere, shot peening, and adjusting the α to β phase ratio to increase mechanical toughness. Surface modification via sandblasting and chemical etching removes the surface oxide layer and forms submicron pores on the surface of the cage, which significantly boosts cell proliferation, differentiation, and osteoblast mineralization. This work exhibits a novel design of Ti-6Al-4V intervertebral fusion cage with biocompatible stiffness, enhanced fatigue life, and improved osteogenic differentiation achieved by reducing residual stress, modifying surface micro-pores, and optimizing microstructure. © 2023, The Authors. All rights reserved.

KW - 3D printing

KW - Biocompatibility

KW - Cell proliferation

KW - Chemical modification

KW - Etching

KW - Fatigue testing

KW - Residual stresses

KW - Shot peening

KW - Stiffness

KW - Ternary alloys

KW - Titanium alloys

KW - Vanadium alloys

KW - 3-D printing

KW - 3D-printing

KW - Dynamic fatigue

KW - Enhanced fatigue lives

KW - Fusion cages

KW - Intervertebral spine cage

KW - Osteogenic differentiation

KW - Surface-modification

KW - Ti-6al-4v

U2 - 10.2139/ssrn.4367770

DO - 10.2139/ssrn.4367770

M3 - Journal Article

SN - 1556-5068

JO - SSRN

JF - SSRN

ER -

Ti-6al-4v Intervertebral Fusion Cage with Compatible Stiffness, Enhanced Fatigue Life, and Osteogenic Differentiation

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Keywords

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