Ticlopidine-induced thrombotic thrombocytopenic purpura: Two case reports treated with plasma exchange plus steroids

Chung Wei Yang, Yung Chang Chen, Po Dunn, Ming-Yang Chang, Ji Tseng Fang*, Chiu Ching Huang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

7 Scopus citations

Abstract

Thrombotic thrombocytopenic purpura (TTP) has a high mortality rate if left untreated with plasma exchange promptly. We report two cases of ticlopidine-induced TTP, which lesser dosages of ticlopidine (200-250 mg/day) were prescribed and were treated with plasma exchange (PE) plus steroids. The first case was treated successfully, but the second case did not respond to our treatment and died of a progressive disease complicated with pneumonia. In sum, we recommend careful use of ticlopidine, regardless of the dosages prescribe and regardless of how long the drug is used. Moreover, the adverse effect of ticlopidine should be closely monitored.

Original languageEnglish
Pages (from-to)851-856
Number of pages6
JournalRenal Failure
Volume23
Issue number6
DOIs
StatePublished - 2001

Keywords

  • Plasma exchange
  • Steroids
  • TTP
  • Thrombotic thrombocytopenic purpura
  • Ticlopidine

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