Time courses and value of circulating microparticles in patients with operable stage non-small cell lung cancer undergoing surgical intervention

Chia Cheng Tseng, Chin Chou Wang, Chang Chun Hsiao, Hung I. Lu, Steve Leu, Huang Chih Chang, Kuo Tung Huang, Wen Feng Fang, Yu Mu Chen, Shih Feng Liu, Cheng Ta Yang, Meng Chih Lin, Hon Kan Yip*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations

Abstract

Microparticles (MPs) are substantially increased in patients with operable stage non-small cell lung cancer (NSCLC) prior to lung resection surgery. This study tested the hypothesis that there is a decrease in MPs after surgical intervention. Between March 2012 and January 2015, 33 patients who had operable stage NSCLC were consecutively and prospectively enrolled into the study. Additionally, 31 healthy subjects who were consecutively enrolled in the study period served as age- and gender-matched controls. Circulating MPs (EDAc-MPs, EDAp-MPs, PDAc-MPs, PDAp-MPs) were measured by flow cytometry once in control subjects and twice (i.e., prior to and three months later after surgical intervention) in NSCLC patients. Compared with control subjects, these four types of circulating MPs were significantly higher in NSCLC patients prior to operation (all P < 0.005), but did not differ among the controls and NSCLC patients at 3 months after surgery (all P > 0.2). Additionally, a receiver operating characteristic curve (ROC) showed that these four types of MPs were significantly valuable predictors for detecting early stage NSCLC (all P < 0.004). Circulating MPs which were remarkably increased in the operable stage of NSCLC prior to surgery were substantially decreased 3 months later after surgery. These findings show that circulating MPs might be an accessory biomarker for monitoring those of NSCLC after receiving lung resection surgery.

Original languageEnglish
Pages (from-to)11873-11882
Number of pages10
JournalTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Volume37
Issue number9
DOIs
StatePublished - 01 09 2016

Bibliographical note

Publisher Copyright:
© 2016, International Society of Oncology and BioMarkers (ISOBM).

Keywords

  • Biomarker
  • Circulating level of microparticles
  • Early stage of non-small cell lung cancer
  • Surgical intervention

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