Time of flight dual photon emission computed tomography

Chih Chieh Chiang, Chun Chao Chuang, Yu Ching Ni, Meei Ling Jan, Keh Shih Chuang, Hsin Hon Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Time-of-flight dual photon emission computed tomography (TOF-DuPECT) is an imaging system that can obtain radionuclide distributions using time information recorded from two cascade-decay photons. The potential decay locations in the image space, a hyperbolic response curve, can be determined via time-difference-of-arrival (TDOA) estimations from two instantaneous coincidence photons. In this feasibility study, Monte Carlo simulations were performed to generate list-mode coincidence data. A full-ring positron emission tomography-like detection system geometry was built in the simulation environment. A contrast phantom and a Jaszczak-like phantom filled with Selenium-75 (Se-75) were used to evaluate the image quality. A TOF-DuPECT system with varying coincidence time resolution (CTR) was then evaluated. We used the stochastic origin ensemble (SOE) algorithm to reconstruct images from the recorded list-mode data. The results indicate that the SOE method can be successfully employed for the TOF-DuPECT system and can achieve acceptable image quality when the CTR is less than 100 ps. Therefore, the TOF-DuPECT imaging system is feasible. With the improvement of the detector with time, future implementations and applications of TOF-DuPECT are promising. Further quantitative imaging techniques such as attenuation and scatter corrections for the TOF-DuPECT system will be developed in future.

Original languageEnglish
Article number19514
JournalScientific Reports
Volume10
Issue number1
DOIs
StatePublished - 12 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020, The Author(s).

Fingerprint

Dive into the research topics of 'Time of flight dual photon emission computed tomography'. Together they form a unique fingerprint.

Cite this