Abstract
Background This study was to estimate the incidence rate of cleft lip and/or cleft palate (CL/P) in Taiwan from 1994 to 2013, and to assess the time trend over these years. Methods Retrospective data analysis was performed on records of all newborns with CL/P treated at Chang Gung Craniofacial Center, the only treatment center for CL/P in Taiwan, from 1994 to 2013. Three-year moving average rates were computed and linear regression was used to explore the annual average percentage change. Results From 1994 to 2013, 7282 newborns with CL/P were identified, corresponding to an annual rate of 1.48‰ (95% confidence interval (CI) = 1.45‰–1.52‰). There was a significant decline of rate of cleft lip with or without cleft palate (CL ± P) (−2.9% ± 0.2%, p < 0.0001) but slightly increase of rate of cleft palate (CP) only (+0.2% ± 0.07%, p = 0.004). Conclusion From 1994 to 2013, the annual rate of incidence of CL/P was 1.48‰ in Taiwan. The 2.9% annual decline of the rate was mainly from the CL ± P group, not the CP group.
Original language | English |
---|---|
Pages (from-to) | 150-154 |
Number of pages | 5 |
Journal | Biomedical Journal |
Volume | 39 |
Issue number | 2 |
DOIs | |
State | Published - 01 04 2016 |
Bibliographical note
Publisher Copyright:© 2016 Chang Gung University
Keywords
- Cleft lip
- Cleft palate
- Incidence
- Prenatal diagnosis