Time trend of incidence rates of cleft lip/palate in Taiwan from 1994 to 2013

Wei Jung Chang, Lai Chu See, Lun Jou Lo*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

24 Scopus citations

Abstract

Background This study was to estimate the incidence rate of cleft lip and/or cleft palate (CL/P) in Taiwan from 1994 to 2013, and to assess the time trend over these years. Methods Retrospective data analysis was performed on records of all newborns with CL/P treated at Chang Gung Craniofacial Center, the only treatment center for CL/P in Taiwan, from 1994 to 2013. Three-year moving average rates were computed and linear regression was used to explore the annual average percentage change. Results From 1994 to 2013, 7282 newborns with CL/P were identified, corresponding to an annual rate of 1.48‰ (95% confidence interval (CI) = 1.45‰–1.52‰). There was a significant decline of rate of cleft lip with or without cleft palate (CL ± P) (−2.9% ± 0.2%, p < 0.0001) but slightly increase of rate of cleft palate (CP) only (+0.2% ± 0.07%, p = 0.004). Conclusion From 1994 to 2013, the annual rate of incidence of CL/P was 1.48‰ in Taiwan. The 2.9% annual decline of the rate was mainly from the CL ± P group, not the CP group.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalBiomedical Journal
Volume39
Issue number2
DOIs
StatePublished - 01 04 2016

Bibliographical note

Publisher Copyright:
© 2016 Chang Gung University

Keywords

  • Cleft lip
  • Cleft palate
  • Incidence
  • Prenatal diagnosis

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