Tissue macrophages: Heterogeneity and functions

Siamon Gordon*, Annette Plüddemann

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

441 Scopus citations

Abstract

Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance of dead and senescent cells, but also through trophic, regulatory and repair functions. In this review, we describe macrophage phenotypic heterogeneity in different tissue environments, drawing particular attention to organ-specific functions.

Original languageEnglish
Article number53
JournalBMC Biology
Volume15
Issue number1
DOIs
StatePublished - 29 06 2017

Bibliographical note

Publisher Copyright:
© 2017 Gordon et al.

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