Tolerance of the fetus by the maternal immune system: Role of inflammatory mediators at the feto-maternal interface

Colette Kanellopoulos-Langevin*, Stéphane M. Caucheteux, Philippe Verbeke, David M. Ojcius

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations

Abstract

The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and the innate immune system at the feto-maternal interface, citing examples of the role played by microbial infections in fetal demise.

Original languageEnglish
Article number121
JournalReproductive Biology and Endocrinology
Volume1
DOIs
StatePublished - 02 12 2003
Externally publishedYes

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