Tonic suppression of baroreceptor reflex by endogenous neurotensin in the rat

Chiung Tong Chen; Julie Y.H. Chan; Charles D. Barnes; Samuel H.H. Chan

doi:10.1016/0167-0115(90)90061-Z

Tonic suppression of baroreceptor reflex by endogenous neurotensin in the rat

Chiung Tong Chen
, Julie Y.H. Chan
, Charles D. Barnes
, Samuel H.H. Chan^*

^*Corresponding author for this work

National Yang Ming Chiao Tung University
Washington State University Pullman

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

We evaluated the modulatory role of endogenous neurotensin (NT) in baroreceptor reflex (BRR) response in Sprague-Dawley rats anesthetized with pentobarbital sodium. Intracerebroventricular (i.c.v.) administration of NT (15 or 30 nmol) significantly reduced the sensitivity of the BRR response. Blocking the endogenous activity of the tridecapeptide with its specific antagonist, (d-Trp¹¹)-NT (4 or 8 nmol) or antiserum against NT (1 : 20); or inhibiting the aminopeptidases with bestatin (200 nmol), on the other hand, promoted a potentiation of BRR response. When administered together with bestatin (200 nmol), the suppressive effect of NT (15 nmol) on the BRR response was further enhanced, as was the augmentative action of (d-Trp¹¹)-NT (4 nmol). Upon microinjection into the bilateral nucleus tractus solitarius (NTS), NT (600 pmol) and (d-Trp¹¹)-NT (150 pmol) respectively elicited a reduction and enhancement of the BRR response. These results suggest that neurons that contain NT may participate in central cardiovascular regulation by tonically suppressing the BRR, possibly via an action on the NTS where baroreceptor afferents terminate.

Original language	English
Pages (from-to)	23-37
Number of pages	15
Journal	Regulatory Peptides
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/0167-0115(90)90061-Z
State	Published - 27 03 1990
Externally published	Yes

Keywords

(d-Trp)-neurotensin
Baroreceptor reflex sensitivity
Bestatin
Neurotensin
Neurotensin antiserum
Nucleus tractus solitarius
Rat

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title = "Tonic suppression of baroreceptor reflex by endogenous neurotensin in the rat",

abstract = "We evaluated the modulatory role of endogenous neurotensin (NT) in baroreceptor reflex (BRR) response in Sprague-Dawley rats anesthetized with pentobarbital sodium. Intracerebroventricular (i.c.v.) administration of NT (15 or 30 nmol) significantly reduced the sensitivity of the BRR response. Blocking the endogenous activity of the tridecapeptide with its specific antagonist, (d-Trp11)-NT (4 or 8 nmol) or antiserum against NT (1 : 20); or inhibiting the aminopeptidases with bestatin (200 nmol), on the other hand, promoted a potentiation of BRR response. When administered together with bestatin (200 nmol), the suppressive effect of NT (15 nmol) on the BRR response was further enhanced, as was the augmentative action of (d-Trp11)-NT (4 nmol). Upon microinjection into the bilateral nucleus tractus solitarius (NTS), NT (600 pmol) and (d-Trp11)-NT (150 pmol) respectively elicited a reduction and enhancement of the BRR response. These results suggest that neurons that contain NT may participate in central cardiovascular regulation by tonically suppressing the BRR, possibly via an action on the NTS where baroreceptor afferents terminate.",

keywords = "(d-Trp)-neurotensin, Baroreceptor reflex sensitivity, Bestatin, Neurotensin, Neurotensin antiserum, Nucleus tractus solitarius, Rat",

author = "Chen, \{Chiung Tong\} and Chan, \{Julie Y.H.\} and Barnes, \{Charles D.\} and Chan, \{Samuel H.H.\}",

year = "1990",

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AU - Chen, Chiung Tong

AU - Chan, Julie Y.H.

AU - Barnes, Charles D.

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PY - 1990/3/27

Y1 - 1990/3/27

N2 - We evaluated the modulatory role of endogenous neurotensin (NT) in baroreceptor reflex (BRR) response in Sprague-Dawley rats anesthetized with pentobarbital sodium. Intracerebroventricular (i.c.v.) administration of NT (15 or 30 nmol) significantly reduced the sensitivity of the BRR response. Blocking the endogenous activity of the tridecapeptide with its specific antagonist, (d-Trp11)-NT (4 or 8 nmol) or antiserum against NT (1 : 20); or inhibiting the aminopeptidases with bestatin (200 nmol), on the other hand, promoted a potentiation of BRR response. When administered together with bestatin (200 nmol), the suppressive effect of NT (15 nmol) on the BRR response was further enhanced, as was the augmentative action of (d-Trp11)-NT (4 nmol). Upon microinjection into the bilateral nucleus tractus solitarius (NTS), NT (600 pmol) and (d-Trp11)-NT (150 pmol) respectively elicited a reduction and enhancement of the BRR response. These results suggest that neurons that contain NT may participate in central cardiovascular regulation by tonically suppressing the BRR, possibly via an action on the NTS where baroreceptor afferents terminate.

AB - We evaluated the modulatory role of endogenous neurotensin (NT) in baroreceptor reflex (BRR) response in Sprague-Dawley rats anesthetized with pentobarbital sodium. Intracerebroventricular (i.c.v.) administration of NT (15 or 30 nmol) significantly reduced the sensitivity of the BRR response. Blocking the endogenous activity of the tridecapeptide with its specific antagonist, (d-Trp11)-NT (4 or 8 nmol) or antiserum against NT (1 : 20); or inhibiting the aminopeptidases with bestatin (200 nmol), on the other hand, promoted a potentiation of BRR response. When administered together with bestatin (200 nmol), the suppressive effect of NT (15 nmol) on the BRR response was further enhanced, as was the augmentative action of (d-Trp11)-NT (4 nmol). Upon microinjection into the bilateral nucleus tractus solitarius (NTS), NT (600 pmol) and (d-Trp11)-NT (150 pmol) respectively elicited a reduction and enhancement of the BRR response. These results suggest that neurons that contain NT may participate in central cardiovascular regulation by tonically suppressing the BRR, possibly via an action on the NTS where baroreceptor afferents terminate.

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KW - Bestatin

KW - Neurotensin

KW - Neurotensin antiserum

KW - Nucleus tractus solitarius

KW - Rat

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DO - 10.1016/0167-0115(90)90061-Z

M3 - 文章

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JO - Regulatory Peptides

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ER -

Tonic suppression of baroreceptor reflex by endogenous neurotensin in the rat

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Keywords

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