Topical sucralfate for pain after oral CO 2 laser surgery: A prospective, randomized, controlled trial

Chau Shiang Guo, Hui Ching Chuang, Chih Yen Chien*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Purpose: The aim of this study was to assess the effect of topical sucralfate on postoperative pain scores and other secondary outcomes including the frequency and duration of analgesic use and postoperative bleeding episodes after CO 2 laser treatment of oral leukoplakia. Patients and Methods: In this prospective trial, a total of 80 patients were randomized into the sucralfate group (n = 40) or the control group (n = 40). Postoperative pain scores, the frequency and duration of analgesic requirements, and postoperative wound bleeding episodes were compared between the 2 groups from the operative day to postoperative day 6. Results: Patients in the sucralfate group experienced significantly less postoperative pain on postoperative days 1 and 2. Although there was no significant difference in frequency and duration of analgesic use between the 2 groups, a trend toward lower frequency and fewer days of analgesic use in the sucralfate group was observed. Conclusions: This study demonstrated the efficacy of topical sucralfate application in diminishing postoperative pain after CO 2 laser therapy for oral leukoplakia. Topical sucralfate can be considered a feasible adjuvant medication for the control of pain after CO 2 laser treatment of oral leukoplakia.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume33
Issue number1
DOIs
StatePublished - 01 2012

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