TY - JOUR
T1 - Total lesion glycolysis
T2 - A possible new prognostic parameter in oral cavity squamous cell carcinoma
AU - Liao, Chun Ta
AU - Abd El-Hafez, Yasser G.
AU - Moustafa, Hosna M.
AU - Khalil, Haytham F.
AU - Yen, Tzu Chen
PY - 2013/3
Y1 - 2013/3
N2 - Objectives: We sought to determine potential prognostic value of total lesion glycolysis (TLG) calculated from combined positron emission tomography/computed tomography (PET/CT) in patients with oral cavity squamous cell carcinoma (OSCC). Materials and methods: We prospectively studied 126 patients with OSCC who underwent PET/CT before definitive treatment by radical surgery. The metabolic tumor volume (MTV) was calculated for the primary tumor according to an absolute standardized uptake value (SUV) of 3. TLG was calculated as MTV × the average SUV. The nodal SUVmax was also recorded. The median value of SUVmax and TLG were used to divide the patients into two categories (high and low). Patients were followed up until death or for at least 24 months from their surgery. Disease-free (DFS) and disease-specific survivals (DSS) were the main outcome measures. Results: The median TLG of the primary tumor (TTLG) was 71.4, and the median nodal SUVmax (NSUV) was 7.5. Patients with high TTLG (≥median) had a 2-year DFS of 52% whereas the DFS was 74% for those with a low TTLG (P = 0.007); the 2-year-DSS rates were 53% vs. 84%, respectively (P < 0.001). Similarly, patients with high NSUVmax (≥median) had a 2-year DFS of 42% vs. 70% for patients with a low NSUVmax (P = 0.001); the 2-year-DSS rates were 39% vs. 78%, respectively (P < 0.001). In multivariate analyses, TTLG, NSUVmax, and pathological nodal status were independent prognostic factors for the 2-year DSS. A 3-point prognostic scoring system was formulated based on the presence or absence of the independent factors. Patients with positive neck nodes, high NSUVmax, and high TTLG (score 3) had a 32-fold higher risk of cancer death compared with those lacking such risk factors (2-year-DSS = 26% vs. 97%, P < 0.001). Conclusion: Primary tumor TLG is an independent prognostic factor for cancer control and survival in patients with OSCC. A prognostic scoring system that includes primary tumor TLG, nodal SUVmax, and pathological neck status may be useful for risk stratification in this group of patients.
AB - Objectives: We sought to determine potential prognostic value of total lesion glycolysis (TLG) calculated from combined positron emission tomography/computed tomography (PET/CT) in patients with oral cavity squamous cell carcinoma (OSCC). Materials and methods: We prospectively studied 126 patients with OSCC who underwent PET/CT before definitive treatment by radical surgery. The metabolic tumor volume (MTV) was calculated for the primary tumor according to an absolute standardized uptake value (SUV) of 3. TLG was calculated as MTV × the average SUV. The nodal SUVmax was also recorded. The median value of SUVmax and TLG were used to divide the patients into two categories (high and low). Patients were followed up until death or for at least 24 months from their surgery. Disease-free (DFS) and disease-specific survivals (DSS) were the main outcome measures. Results: The median TLG of the primary tumor (TTLG) was 71.4, and the median nodal SUVmax (NSUV) was 7.5. Patients with high TTLG (≥median) had a 2-year DFS of 52% whereas the DFS was 74% for those with a low TTLG (P = 0.007); the 2-year-DSS rates were 53% vs. 84%, respectively (P < 0.001). Similarly, patients with high NSUVmax (≥median) had a 2-year DFS of 42% vs. 70% for patients with a low NSUVmax (P = 0.001); the 2-year-DSS rates were 39% vs. 78%, respectively (P < 0.001). In multivariate analyses, TTLG, NSUVmax, and pathological nodal status were independent prognostic factors for the 2-year DSS. A 3-point prognostic scoring system was formulated based on the presence or absence of the independent factors. Patients with positive neck nodes, high NSUVmax, and high TTLG (score 3) had a 32-fold higher risk of cancer death compared with those lacking such risk factors (2-year-DSS = 26% vs. 97%, P < 0.001). Conclusion: Primary tumor TLG is an independent prognostic factor for cancer control and survival in patients with OSCC. A prognostic scoring system that includes primary tumor TLG, nodal SUVmax, and pathological neck status may be useful for risk stratification in this group of patients.
KW - Fluorodeoxyglucose
KW - Oral cancer
KW - Positron emission tomography computed tomography
KW - Prognosis
KW - Squamous cell carcinoma
KW - Total lesion glycolysis
KW - Tumor volume
UR - https://www.scopus.com/pages/publications/84873411442
U2 - 10.1016/j.oraloncology.2012.09.005
DO - 10.1016/j.oraloncology.2012.09.005
M3 - 文章
C2 - 23036774
AN - SCOPUS:84873411442
SN - 1368-8375
VL - 49
SP - 261
EP - 268
JO - Oral Oncology
JF - Oral Oncology
IS - 3
ER -
