Towards automating micro cellular detection process using micro vortex pump arrays

Raymond H.W. Lam*, Kin Fong Lei, Lei Miao, Zaili Dong, Wing Cheung Law, Yick Keung Suen, Wen J. Li, Aaron Ho Pu Ho, Siu Kai Kong

*Corresponding author for this work

Research output: Contribution to conferenceConference Paperpeer-review

Abstract

This paper reports a polymer based microfluidic analysis system integrated with a surface plasmon resonance (SPR) biosensor for detecting the specific binding of biomolecules and qualitatively monitoring of cell adhesion on the sensor surface. Micropumps, microchannels, and SPR biosensor were integrated into a single polymer (PMMA) based microfluidic system. The integrated system has been studied in its potential application in bio-molecules detection and drug discovery. Two experiments, 1) monitoring the reaction between BSA-BSA antibody, and 2) monitoring the activities of living cells in the presence or absence of trypsin in RPMI-1640 medium, were conducted to show the feasibility of real-time cellular and molecular detection. Based on these successful experimental results we have also developed a computer-controllable vortex micropump system that will eventually automate many bio-molecular detection and drug discovery processes.

Original languageEnglish
Pages66-71
Number of pages6
StatePublished - 2005
Externally publishedYes
EventProceedings of the 2005 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2005 - Monterey, CA, United States
Duration: 24 07 200528 07 2005

Conference

ConferenceProceedings of the 2005 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2005
Country/TerritoryUnited States
CityMonterey, CA
Period24/07/0528/07/05

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