Toxic epidermal necrolysis secondary to Mycoplasma pneumoniae and herpes simplex virus infection

Ching Hsuan Hu, Nai Jen Chang, Shiow Shuh Chuang, Jui Yung Yang*, Weng Hung Chung

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

Abstract

Toxic epidermal necrolysis (TEN) is a life-threatening skin reaction associated with a high mortality rate. Most TEN is induced by drugs, but some cases are caused by other insults. Mycoplasma pneumoniae and herpes simplex virus are the most common infectious pathogens associated with TEN. In identifying the etiology of TEN, it is crucial to include not only a detailed drug history but also potential infection sources. Any suspicious infections should be treated in a timely and efficient manner to improve survival rates. In this article, we report on five patients who developed TEN related to M. pneumoniae and herpes simplex virus infections. We also reviewed the relevant literature. We performed a retrospective medical chart review of five patients with TEN, which was considered secondary to M. pneumoniae and herpes simplex virus infections. We compared patients with infection-induced and drug-induced TEN. We found that patients with infection-induced TEN were younger in age and had lower SCORTEN scores, less renal dysfunction, shorter hospitalization periods, and higher survival rates compared with patients with drug-induced TEN. Identifying the etiology of TEN requiresthe inclusion of not only a detailed drug history but also infection sources, such as M. pneumoniae and herpes simplex virus. Our findings corroborate previously reported clinical and etiologic association with TEN. TEN induced by M. pneumoniae and herpes simplex virus manifested less severe clinical courses than its drug-induced counterpart.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalZhonghua Minguo wai ke yi xue hui za zhi
Volume48
Issue number1
DOIs
StatePublished - 01 02 2015

Bibliographical note

Publisher Copyright:
© 2015.

Keywords

  • Herpes simplex virus
  • Mycoplasma pneumoniae
  • SCORTEN
  • TEN
  • Toxic epidermal necrolysis

Fingerprint

Dive into the research topics of 'Toxic epidermal necrolysis secondary to Mycoplasma pneumoniae and herpes simplex virus infection'. Together they form a unique fingerprint.

Cite this