TY - JOUR
T1 - Toxicities, safeties and clinical response of dacarbazine-based chemotherapy on neuroendocrine tumors in Taiwan population
AU - Chiu, Hwa Yen
AU - Lin, Liang Yu
AU - Chou, Wen Chi
AU - Fang, Wen Liang
AU - Shyr, Yi Ming
AU - Yeh, Yi Chen
AU - Mu-Hsin Chang, Peter
AU - Chen, Ming Han
AU - Hung, Yi Ping
AU - Chao, Yee
AU - Chien, Sheng Hsuan
AU - Chen, Ming Huang
N1 - Publisher Copyright:
© 2017 the Chinese Medical Association
PY - 2018/5
Y1 - 2018/5
N2 - Background: Currently, the role of dacarbazine (DTIC) based chemotherapy in neuroendocrine tumors (NETs) in Asia is unclear. Here, we report the outcomes of dacarbazine (DTIC)-based chemotherapy in Taiwan population. Methods: DTIC alone (250 mg/m 2 /day), or 5-fluorouracil (5-FU, 500 mg/m 2 /day) and DTIC (200 mg/m 2 /day) with or without epirubicin (200 mg/m 2 /day), for 3 days, every 3–4 weeks. Subgroups were analyzed by grading, and by Ki-67 index. Results: 48 patients were reviewed in this study, including 3 had grade 1 tumors, 23 had grade 2, while 22 were grade 3. In grade 3 NEC patients, the tumor Ki-67 index of 21–55% were noted in 8 patients, and >55% in 14 patients. Progression-free survival (PFS) was 5.1 months, and overall survival (OS) was 31.6 months. The PFS (in months) were 12.5 and 1.8 for patients with NETs and neuroendocrine carcinomas (NECs), respectively (p < 0.001). The OS were not reached and 5.9 months for patients with NETs and NECs, respectively (p = 0.001). Patients with NECs were divided into two groups, according to their Ki-67 index. In patients with a tumor Ki-67 index of 21–55%, PFS was 4.1 months, and OS was not reached; in those with a tumor Ki-67 index of >55%, they were 1.5 and 1.8 months, respectively (p < 0.001 and p = 0.013). Conclusion: NETs, and grade 3 NECs, with Ki-67 indices of 20–55% had good responses to DTIC-based chemotherapy, with acceptable side effects. Ki-67 index could predict prognosis for grade 3 NEC patients, and guide further chemotherapy choices.
AB - Background: Currently, the role of dacarbazine (DTIC) based chemotherapy in neuroendocrine tumors (NETs) in Asia is unclear. Here, we report the outcomes of dacarbazine (DTIC)-based chemotherapy in Taiwan population. Methods: DTIC alone (250 mg/m 2 /day), or 5-fluorouracil (5-FU, 500 mg/m 2 /day) and DTIC (200 mg/m 2 /day) with or without epirubicin (200 mg/m 2 /day), for 3 days, every 3–4 weeks. Subgroups were analyzed by grading, and by Ki-67 index. Results: 48 patients were reviewed in this study, including 3 had grade 1 tumors, 23 had grade 2, while 22 were grade 3. In grade 3 NEC patients, the tumor Ki-67 index of 21–55% were noted in 8 patients, and >55% in 14 patients. Progression-free survival (PFS) was 5.1 months, and overall survival (OS) was 31.6 months. The PFS (in months) were 12.5 and 1.8 for patients with NETs and neuroendocrine carcinomas (NECs), respectively (p < 0.001). The OS were not reached and 5.9 months for patients with NETs and NECs, respectively (p = 0.001). Patients with NECs were divided into two groups, according to their Ki-67 index. In patients with a tumor Ki-67 index of 21–55%, PFS was 4.1 months, and OS was not reached; in those with a tumor Ki-67 index of >55%, they were 1.5 and 1.8 months, respectively (p < 0.001 and p = 0.013). Conclusion: NETs, and grade 3 NECs, with Ki-67 indices of 20–55% had good responses to DTIC-based chemotherapy, with acceptable side effects. Ki-67 index could predict prognosis for grade 3 NEC patients, and guide further chemotherapy choices.
KW - Dacarbazine
KW - Ki-67 index
KW - Neuroendocrine carcinoma
KW - Neuroendocrine tumors
KW - Overall survival
KW - Progression-free survival
UR - http://www.scopus.com/inward/record.url?scp=85039037139&partnerID=8YFLogxK
U2 - 10.1016/j.jcma.2017.08.020
DO - 10.1016/j.jcma.2017.08.020
M3 - 文章
C2 - 29287706
AN - SCOPUS:85039037139
SN - 1726-4901
VL - 81
SP - 423
EP - 428
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
IS - 5
ER -