TY - JOUR
T1 - Traditional Chinese medicine for idiopathic precocious puberty
T2 - A hospital-based retrospective observational study
AU - Yu, Chao Hui
AU - Liu, Pi Hua
AU - Van, Yang Hau
AU - Lien, Angela Shin Yu
AU - Huang, Tzu Ping
AU - Yen, Hung Rong
PY - 2014/4
Y1 - 2014/4
N2 - Objectives: To characterize the application of traditional Chinese medicine (TCM) among children with idiopathic precocious puberty (IPP). Design and setting: This study examined data sets from patients diagnosed with IPP at Chang Gung Memorial Hospital between 2010 and 2012. The patients were allocated into three groups according their voluntary choice of treatment modalities: TCM users (received TCM treatment only), Western medicine (WM) users (received WM treatment only), and "no treatment" group (received no medical treatment at all). Main outcome measures: The demographic data of children with IPP were characterized. The prescription patterns and frequencies of TCM for IPP patients were analyzed. The patients' bone maturation rates and the change of predicted height after different approaches were measured as outcomes. Results: There were 3390 patients enrolled in the study. Zhi-Bai-Di-Huang-Wan (70.62%) was the most common herbal formula and Mai-Ya (Hordei Fructus Germinatus) (51.58%) was the most common single herb prescribed for IPP in all of the 2784 prescriptions. The bone maturation rates of TCM users (0.95. ±. 0.20) and WM users (0.69. ±. 0.05) were both decelerated but the "no treatment" group had an accelerated bone maturation rate of 1.33. ±. 0.04. TCM and WM users also had higher predicted height after treatment (1.15. ±. 1.19. cm versus 1.73. ±. 0.29. cm), while the "no treatment" group had a decreased predicted height (-0.52. ±. 0.23. cm). Conclusions: Our study revealed a comprehensive list of TCM prescriptions for IPP patients. Future well-designed, randomized, double-blinded, and placebo-controlled clinical trials are warranted to evaluate the efficacy and safety of TCM for precocity.
AB - Objectives: To characterize the application of traditional Chinese medicine (TCM) among children with idiopathic precocious puberty (IPP). Design and setting: This study examined data sets from patients diagnosed with IPP at Chang Gung Memorial Hospital between 2010 and 2012. The patients were allocated into three groups according their voluntary choice of treatment modalities: TCM users (received TCM treatment only), Western medicine (WM) users (received WM treatment only), and "no treatment" group (received no medical treatment at all). Main outcome measures: The demographic data of children with IPP were characterized. The prescription patterns and frequencies of TCM for IPP patients were analyzed. The patients' bone maturation rates and the change of predicted height after different approaches were measured as outcomes. Results: There were 3390 patients enrolled in the study. Zhi-Bai-Di-Huang-Wan (70.62%) was the most common herbal formula and Mai-Ya (Hordei Fructus Germinatus) (51.58%) was the most common single herb prescribed for IPP in all of the 2784 prescriptions. The bone maturation rates of TCM users (0.95. ±. 0.20) and WM users (0.69. ±. 0.05) were both decelerated but the "no treatment" group had an accelerated bone maturation rate of 1.33. ±. 0.04. TCM and WM users also had higher predicted height after treatment (1.15. ±. 1.19. cm versus 1.73. ±. 0.29. cm), while the "no treatment" group had a decreased predicted height (-0.52. ±. 0.23. cm). Conclusions: Our study revealed a comprehensive list of TCM prescriptions for IPP patients. Future well-designed, randomized, double-blinded, and placebo-controlled clinical trials are warranted to evaluate the efficacy and safety of TCM for precocity.
KW - Complementary and alternative medicine
KW - Precocious puberty
KW - Traditional Chinese medicine
KW - Zhi-Bai-Di-Huang-Wan
UR - https://www.scopus.com/pages/publications/84898788476
U2 - 10.1016/j.ctim.2014.01.002
DO - 10.1016/j.ctim.2014.01.002
M3 - 文章
C2 - 24731897
AN - SCOPUS:84898788476
SN - 0965-2299
VL - 22
SP - 258
EP - 265
JO - Complementary Therapies in Medicine
JF - Complementary Therapies in Medicine
IS - 2
ER -