Transcription-driven DNA supercoiling and gene expression control

Chien Chung Chen, Hai Young Wu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


DNA supercoiling plays important roles in gene expression regulation, although, the underlying mechanisms whereby DNA supercoiling modulates gene expression remain elusive. The fact that the transcription process itself generates DNA supercoiling has further complicated the issue. Transcription-driven DNA supercoiling is local and transient. Such a DNA supercoiling effect is likely to play important roles in controlling complex gene expression regulation. Using the suppression of the leu-500 mutation in Salmonella typhimurium topA mutants as a model system, we put forward our view of the effects of transcription-driven DNA supercoiling on gene expression control.

Original languageEnglish
Pages (from-to)d430-d439
JournalFrontiers in Bioscience - Landmark
StatePublished - 2003
Externally publishedYes


  • Bacterial Stress Response
  • Leu-500 activation
  • Promoter Relay Mechanism
  • Review
  • Transcription Control
  • Transcription-Driven DNA Supercoiling
  • topA


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