Transcripts of the Insulin-like Growth Factors I and II in Human Hepatoma

Tsung Sheng Su*, Wing Yiu Liu, Shou Hwa Han, Martin Jansen, Teresa L. Yang-Fen, Fang Ku P'eng, Cheng Kung Chou

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

97 Scopus citations

Abstract

Using complementary DNAs of human insulin-like growth factors as probes, expressions of the insulin-like growth factors I and II mRNA were examined in seven human hepatoma tissues and their adjacent nontumorous livers. The level of insulin-like growth factor I mRNA in hepatoma was lower than that in the nontumorous liver control. This phenomenon was probably caused by the low expression of human growth hormone receptor in hepatoma tissues. The levels of insulin-like growth factor II mRNA vary among hepatomas. Some show elevated expression; some have diminished expression compared to their nontumorous liver counterparts. In four of the seven hepatomas, expression of fetal forms of insulin-like growth factor II transcripts was observed and may represent dedifferentiation of insulin-like growth factor II expression during hepatocarcinogenesis.

Original languageEnglish
Pages (from-to)1773-1777
Number of pages5
JournalCancer Research
Volume49
Issue number7
StatePublished - 01 04 1989
Externally publishedYes

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