Transient increase in circulating myeloid-derived suppressor cells after partial bladder outlet obstruction

Wei Yu Lin*, Ching Chuan Hsieh, Teng Yao Yang, Miaw Ling Chen, Li Ying Huang, Yi Pai Lin, Pey Jium Chang, Robert M. Levin, Yau-Huei Wei

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations

Abstract

Purpose: Partial bladder outlet obstruction causes a significant increase in tissue and systemic oxidative stress markers and tissue inflammatory cytokine levels. Myeloid-derived suppressor cells, γ, IL-10 and aldosterone are believed to be associated with oxidative stress and inflammation. We investigated alterations in plasma myeloid-derived suppressor cells, γ, IL-10 and aldosterone levels in partial bladder outlet obstruction and after its reversal.

Materials and Methods: Rats with surgically induced partial bladder outlet obstruction were divided into 4 groups of 3 each, including sham treated, 4-week obstruction, and 4 and 8-week obstruction with relief. Plasma levels of circulating myeloid-derived suppressor cells, γ, IL-10 and aldosterone were assessed by flow cytometry or enzyme-linked immunosorbent assay.

Results: The circulating myeloid-derived suppressor cell level was markedly increased in the obstruction group compared to the sham treated group and it returned to normal in the 4 and 8-week obstruction with relief groups. Plasma γ, IL-10 and aldosterone were similarly increased in the obstruction group and returned to normal in the 4 and 8-week obstruction with relief groups.

Conclusions: Levels of circulating myeloid-derived suppressor cells, γ, IL-10 and aldosterone were increased in rats with partial bladder outlet obstruction but returned to normal after reversal. This suggests that an increase in these parameters may be a good predictive indicator of patients at increased risk for urinary symptoms.

Original languageEnglish
Pages (from-to)1569-1573
Number of pages5
JournalJournal of Urology
Volume192
Issue number5
DOIs
StatePublished - 01 11 2014

Bibliographical note

Publisher Copyright:
© 2014 American Urological Association Education and Research, Inc.

Keywords

  • cell differentiation
  • cytokines
  • inflammation
  • oxidative stress
  • urinary bladder neck obstruction

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