Transient neurological disturbances induced by the chemotherapy of high- dose methotrexate for osteogenic sarcoma

M. C. Kiu; C. C. Liaw; T. S. Yang; G. M. Lal; S. N. Hsi; C. S. Lu

doi:10.1097/00001813-199408000-00015

Transient neurological disturbances induced by the chemotherapy of high- dose methotrexate for osteogenic sarcoma

M. C. Kiu^*, C. C. Liaw, T. S. Yang, G. M. Lal, S. N. Hsi, C. S. Lu

^*Corresponding author for this work

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma. This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m² by 6 h continuous infusion) with leucovorin rescue. Laboratory evaluations disclosed normal electrolytes, hemograms and non-toxic serum MTX levels at the onset of the symptoms. Computed tomography of the brain was normal but electroencephalography showed focal theta and delta slow waves over the right temporal-parietal-occipital area. The neurological symptoms resolved completely within 72 h.

Original language	English
Pages (from-to)	480-482
Number of pages	3
Journal	Anti-Cancer Drugs
Volume	5
Issue number	4
DOIs	https://doi.org/10.1097/00001813-199408000-00015
State	Published - 1994
Externally published	Yes

Keywords

High-dose methotrexate
neurotoxicity
osteogenic sarcoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00001813-199408000-00015

Cite this

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title = "Transient neurological disturbances induced by the chemotherapy of high- dose methotrexate for osteogenic sarcoma",

abstract = "Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma. This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue. Laboratory evaluations disclosed normal electrolytes, hemograms and non-toxic serum MTX levels at the onset of the symptoms. Computed tomography of the brain was normal but electroencephalography showed focal theta and delta slow waves over the right temporal-parietal-occipital area. The neurological symptoms resolved completely within 72 h.",

keywords = "High-dose methotrexate, neurotoxicity, osteogenic sarcoma",

author = "Kiu, {M. C.} and Liaw, {C. C.} and Yang, {T. S.} and Lal, {G. M.} and Hsi, {S. N.} and Lu, {C. S.}",

year = "1994",

doi = "10.1097/00001813-199408000-00015",

language = "英语",

volume = "5",

pages = "480--482",

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TY - JOUR

T1 - Transient neurological disturbances induced by the chemotherapy of high- dose methotrexate for osteogenic sarcoma

AU - Kiu, M. C.

AU - Liaw, C. C.

AU - Yang, T. S.

AU - Lal, G. M.

AU - Hsi, S. N.

AU - Lu, C. S.

PY - 1994

Y1 - 1994

N2 - Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma. This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue. Laboratory evaluations disclosed normal electrolytes, hemograms and non-toxic serum MTX levels at the onset of the symptoms. Computed tomography of the brain was normal but electroencephalography showed focal theta and delta slow waves over the right temporal-parietal-occipital area. The neurological symptoms resolved completely within 72 h.

AB - Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma. This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue. Laboratory evaluations disclosed normal electrolytes, hemograms and non-toxic serum MTX levels at the onset of the symptoms. Computed tomography of the brain was normal but electroencephalography showed focal theta and delta slow waves over the right temporal-parietal-occipital area. The neurological symptoms resolved completely within 72 h.

KW - High-dose methotrexate

KW - neurotoxicity

KW - osteogenic sarcoma

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U2 - 10.1097/00001813-199408000-00015

DO - 10.1097/00001813-199408000-00015

M3 - 文章

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AN - SCOPUS:0028000918

SN - 0959-4973

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JO - Anti-Cancer Drugs

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IS - 4

ER -

Transient neurological disturbances induced by the chemotherapy of high- dose methotrexate for osteogenic sarcoma

Abstract

Keywords

UN SDGs

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