Treatment of psoriatic nails with indigo naturalis oil extract: A non-controlled pilot study

Yin-Ku Lin; Lai Chu See; Ya Ching Chang; Yu Huei Huang; Jiun Liang Chen; Teng Cheng Tsou; Yann Lii Leu; Yu Ming Shen

doi:10.1159/000333362

Treatment of psoriatic nails with indigo naturalis oil extract: A non-controlled pilot study

Yin-Ku Lin^*, Lai Chu See, Ya Ching Chang, Yu Huei Huang, Jiun Liang Chen, Teng Cheng Tsou, Yann Lii Leu, Yu Ming Shen

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

24 Scopus citations

Abstract

Background: In the treatment of nail psoriasis, standardized therapeutic regimens are currently lacking. Objective: To evaluate the therapeutic efficacy of indigo naturalis oil extract in patients with nail psoriasis. Methods: Patients with nail psoriasis applied indigo naturalis oil extract on affected nails twice daily for 24 weeks. Efficacy was evaluated using the Nail Psoriasis Severity Index (NAPSI) and modified target NAPSI for the single most severely affected nail. Results: Twenty-eight out of 32 patients completed the study. The mean NAPSI was 36.1 ± 14.7 at baseline and decreased to 14.9 ± 11.1 at week 24 while the mean modified target NAPSI was 11.7 ± 3.9 at baseline and decreased to 3.6 ± 3.2 at week 24. Conclusions: Indigo naturalis oil extract appeared to improve nail psoriasis. Although preliminary, these results indicate that it could provide a novel therapeutic option for nail psoriasis, a disease notoriously difficult to treat.

Original language	English
Pages (from-to)	239-243
Number of pages	5
Journal	Dermatology
Volume	223
Issue number	3
DOIs	https://doi.org/10.1159/000333362
State	Published - 12 2011

Keywords

Indigo naturalis
Indirubin
Modified target Nail Psoriasis Severity Index
Nail Psoriasis Severity Index
Psoriatic nails

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10.1159/000333362

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title = "Treatment of psoriatic nails with indigo naturalis oil extract: A non-controlled pilot study",

abstract = "Background: In the treatment of nail psoriasis, standardized therapeutic regimens are currently lacking. Objective: To evaluate the therapeutic efficacy of indigo naturalis oil extract in patients with nail psoriasis. Methods: Patients with nail psoriasis applied indigo naturalis oil extract on affected nails twice daily for 24 weeks. Efficacy was evaluated using the Nail Psoriasis Severity Index (NAPSI) and modified target NAPSI for the single most severely affected nail. Results: Twenty-eight out of 32 patients completed the study. The mean NAPSI was 36.1 ± 14.7 at baseline and decreased to 14.9 ± 11.1 at week 24 while the mean modified target NAPSI was 11.7 ± 3.9 at baseline and decreased to 3.6 ± 3.2 at week 24. Conclusions: Indigo naturalis oil extract appeared to improve nail psoriasis. Although preliminary, these results indicate that it could provide a novel therapeutic option for nail psoriasis, a disease notoriously difficult to treat.",

keywords = "Indigo naturalis, Indirubin, Modified target Nail Psoriasis Severity Index, Nail Psoriasis Severity Index, Psoriatic nails",

author = "Yin-Ku Lin and See, \{Lai Chu\} and Chang, \{Ya Ching\} and Huang, \{Yu Huei\} and Chen, \{Jiun Liang\} and Tsou, \{Teng Cheng\} and Leu, \{Yann Lii\} and Shen, \{Yu Ming\}",

year = "2011",

month = dec,

doi = "10.1159/000333362",

language = "英语",

volume = "223",

pages = "239--243",

journal = "Dermatology",

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T1 - Treatment of psoriatic nails with indigo naturalis oil extract

T2 - A non-controlled pilot study

AU - Lin, Yin-Ku

AU - See, Lai Chu

AU - Chang, Ya Ching

AU - Huang, Yu Huei

AU - Chen, Jiun Liang

AU - Tsou, Teng Cheng

AU - Leu, Yann Lii

AU - Shen, Yu Ming

PY - 2011/12

Y1 - 2011/12

N2 - Background: In the treatment of nail psoriasis, standardized therapeutic regimens are currently lacking. Objective: To evaluate the therapeutic efficacy of indigo naturalis oil extract in patients with nail psoriasis. Methods: Patients with nail psoriasis applied indigo naturalis oil extract on affected nails twice daily for 24 weeks. Efficacy was evaluated using the Nail Psoriasis Severity Index (NAPSI) and modified target NAPSI for the single most severely affected nail. Results: Twenty-eight out of 32 patients completed the study. The mean NAPSI was 36.1 ± 14.7 at baseline and decreased to 14.9 ± 11.1 at week 24 while the mean modified target NAPSI was 11.7 ± 3.9 at baseline and decreased to 3.6 ± 3.2 at week 24. Conclusions: Indigo naturalis oil extract appeared to improve nail psoriasis. Although preliminary, these results indicate that it could provide a novel therapeutic option for nail psoriasis, a disease notoriously difficult to treat.

AB - Background: In the treatment of nail psoriasis, standardized therapeutic regimens are currently lacking. Objective: To evaluate the therapeutic efficacy of indigo naturalis oil extract in patients with nail psoriasis. Methods: Patients with nail psoriasis applied indigo naturalis oil extract on affected nails twice daily for 24 weeks. Efficacy was evaluated using the Nail Psoriasis Severity Index (NAPSI) and modified target NAPSI for the single most severely affected nail. Results: Twenty-eight out of 32 patients completed the study. The mean NAPSI was 36.1 ± 14.7 at baseline and decreased to 14.9 ± 11.1 at week 24 while the mean modified target NAPSI was 11.7 ± 3.9 at baseline and decreased to 3.6 ± 3.2 at week 24. Conclusions: Indigo naturalis oil extract appeared to improve nail psoriasis. Although preliminary, these results indicate that it could provide a novel therapeutic option for nail psoriasis, a disease notoriously difficult to treat.

KW - Indigo naturalis

KW - Indirubin

KW - Modified target Nail Psoriasis Severity Index

KW - Nail Psoriasis Severity Index

KW - Psoriatic nails

UR - https://www.scopus.com/pages/publications/84355162076

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DO - 10.1159/000333362

M3 - 文章

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AN - SCOPUS:84355162076

SN - 1018-8665

VL - 223

SP - 239

EP - 243

JO - Dermatology

JF - Dermatology

IS - 3

ER -

Treatment of psoriatic nails with indigo naturalis oil extract: A non-controlled pilot study

Abstract

Keywords

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