Triterpenoids from the roots of Rhaphiolepis indica var. tashiroi and their anti-inflammatory activity

Chu Hung Lin; Hsun Shuo Chang; Hsiang Ruei Liao; Ih Sheng Chen; Ian Lih Tsai

doi:10.3390/ijms14058890

Triterpenoids from the roots of Rhaphiolepis indica var. tashiroi and their anti-inflammatory activity

Chu Hung Lin, Hsun Shuo Chang, Hsiang Ruei Liao, Ih Sheng Chen, Ian Lih Tsai^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3-10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1-10 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC₅₀ value of 16.50 μM.

Original language	English
Pages (from-to)	8890-8898
Number of pages	9
Journal	International Journal of Molecular Sciences
Volume	14
Issue number	5
DOIs	https://doi.org/10.3390/ijms14058890
State	Published - 05 2013

Keywords

Anti-inflammatory activity
Inhibition of superoxide production
Rhaphiolepis indica var. tashiroi
Roots
Rosaceae
Triterpenoids

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10.3390/ijms14058890

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@article{534c116741724cfbb690aee6a26932c2,

title = "Triterpenoids from the roots of Rhaphiolepis indica var. tashiroi and their anti-inflammatory activity",

abstract = "Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3-10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1-10 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC50 value of 16.50 μM.",

keywords = "Anti-inflammatory activity, Inhibition of superoxide production, Rhaphiolepis indica var. tashiroi, Roots, Rosaceae, Triterpenoids",

author = "Lin, {Chu Hung} and Chang, {Hsun Shuo} and Liao, {Hsiang Ruei} and Chen, {Ih Sheng} and Tsai, {Ian Lih}",

year = "2013",

month = may,

doi = "10.3390/ijms14058890",

language = "英语",

volume = "14",

pages = "8890--8898",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

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number = "5",

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T1 - Triterpenoids from the roots of Rhaphiolepis indica var. tashiroi and their anti-inflammatory activity

AU - Lin, Chu Hung

AU - Chang, Hsun Shuo

AU - Liao, Hsiang Ruei

AU - Chen, Ih Sheng

AU - Tsai, Ian Lih

PY - 2013/5

Y1 - 2013/5

N2 - Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3-10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1-10 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC50 value of 16.50 μM.

AB - Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3-10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1-10 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC50 value of 16.50 μM.

KW - Anti-inflammatory activity

KW - Inhibition of superoxide production

KW - Rhaphiolepis indica var. tashiroi

KW - Roots

KW - Rosaceae

KW - Triterpenoids

UR - http://www.scopus.com/inward/record.url?scp=84876907981&partnerID=8YFLogxK

U2 - 10.3390/ijms14058890

DO - 10.3390/ijms14058890

M3 - 文章

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AN - SCOPUS:84876907981

SN - 1661-6596

VL - 14

SP - 8890

EP - 8898

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 5

ER -

Triterpenoids from the roots of Rhaphiolepis indica var. tashiroi and their anti-inflammatory activity

Abstract

Keywords

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